Browsing by Author "08505bcd-df5d-45e9-aae4-bf0d5ca76d8f"
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Capsaicin and piperine as functional excipients for improved drug delivery across nasal epithelial models
Gerber, Werner; Steyn, Dewald; Kotzé, Awie; Svitina, Hanna; Weldon, Ché; Hamman, Josias (Thieme, 2019)The fruit from various pepper plants has been employed for the seasoning of food, as perfuming agents, and also as traditional medicines. Phytochemicals isolated from different pepper species have been found to modulate ... -
Development and evaluation of a double-phase multiple-unit dosage form for enhanced insulin intestinal delivery
De Bruyn, Suzette; Willers, Clarissa; Steyn, Dewald; Steenekamp, Jan; Hamman, Josias (Bentham Science, 2018)Background: The oral route is the most preferred route of administration for selfmedication, but poor membrane permeability and pre-systemic degradation are key challenges that need to be addressed. Objective: The purpose ... -
Intestinal drug absorption enhancement by Aloe vera gel and whole leaf extract: in vitro investigations into the mechanisms of action
Haasbroek, Anja; Willers, Clarissa; Glyn, Matthew; Du Plessis, Lissinda; Hamman, Josias (MDPI, 2019)The co-administration of absorption enhancing agents with macromolecular drugs (e.g., protein and peptide drugs) has been identified as a means to improve the oral bioavailability of these drugs. Absorption-enhancing agents ... -
Treatment of skin disorders with aloe materials
Svitina, Hanna; Swanepoel, Roan; Rossouw, Jacques; Netshimbupfe, Happiness; Gouws, Chrisna; Hamman, Josias (Bentham Science, 2019)The skin is the largest organ and functions as a barrier to protect the underlying tissues against the elements and pathogens, while also fulfilling many physiological roles and biochemical functions such as preventing ...