Browsing by Author "4f1589ae-9312-4076-a562-e78757586882"
Now showing items 1-7 of 7
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The cardiovascular safety of Pheroid® in the conscious rat
Van Wyk, Riaan; Guth, Brian D.; Grobler, Anne F.; Bester, Cor (Elsevier, 2019)The Pheroid® technology is a patented colloidal drug delivery system comprised of a dispersed oil phase of omega 3 and omega 6 fatty acids emulsified in N2O saturated water. Pheroid® has pharmaceutical applicability for ... -
Drug safety Africa: an overview of safety pharmacology & toxicology in South Africa
Guth, Brian D.; Grobler, Anne F.; Frazier, Kendall S.; Greiter-Wilke, Andrea; Herzyk, Danuta (Elsevier, 2019)This meeting report is based on presentations given at the first Drug Safety Africa Meeting in Potchefstroom, South Africa from November 20–22, 2018 at the North-West University campus. There were 134 attendees (including ... -
In vitro determination of the preclinical safety of Pheroid® doxorubicin formulations using patch clamp assays
Leussa, Nyango-Nkeh Adrienne; Grobler, Anne F. (Elsevier, 2019)One of the most active, widely used and well-known drugs in breast cancer chemotherapy, doxorubicin (DOX), is an anthracycline ring antibiotic derived from the bacteria Streptomyces peucetius. Its clinical use is however, ... -
An investigation into the bioavailability of a peroral cannabinoid-Pheroid® formulation
Erasmus, Stephanie; Cloete, Theunis; Scholtz, Liezl-Marie; Grobler, Anne F.; Magwasa, Martin S. (Elsevier, 2019)Cannabidiol (CBD), a phytocannabinoid isolated from the Cannabis sativa plant, has been investigated for its medicinal properties including anti-psychotic, anti- emetic, anti-inflammatory, anxiolytic and anti- convulsant ... -
Nano- and Pheroid technologies for development of foliar iron fertilizers and iron biofortification of soybean grown in South Africa
Knijnenburg, Jesper T.N.; Grobler, Anne F.; Hilty, Florentine M.; Oelofse, Janro; Buitendag, Riaan (Springer, 2019)Background Foliar iron (Fe) fertilization of crops may increase Fe concentrations in edible portions of plants and improve yield in soils with low available Fe. However, the role of foliar Fe fertilization in increasing ... -
The selective targeting of cancer cells by using Pheroid® as a drug delivery system
Bakker, Cornel; Grobler, Anne F.; Okem, A. (Elsevier, 2019)Pheroid® is a drug delivery system with possible use in the treatment of chronic diseases such as cancer and that enhances the efficacy of the treatment of chronic diseases [1]. Current cancer treatment is non-selective, ... -
Therapeutic use and pharmacological safety of herbal medicines
Bekele, Bisrat Sissay; Pheiffer, Wihan; Grobler, Anne F. (Elsevier, 2019)In general, N80% of the world's population relies on traditional medicine for their primary healthcare [1]. The use of complementary herbal medicine provides an alternative option to modern allopathic treatment for ...