Browsing by Author "fb603321-745b-4fbe-b998-ce44cf9939f1"
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Establishing three-dimensional cell culture models to measure biotransformation and toxicity
Calitz, Carlemi (North-West University, Potchefstroom Campus, 2018)A great proportion of new chemical entities will be terminated from the clinical drug development pipeline as a result of deficiencies in drug absorption, distribution, biotransformation and elimination as well as potential ... -
A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model
Calitz, Carlemi; Hamman, Josias H.; Gouws, Chrisna; Wrzesinski, Krzysztof; Fey, Stephen J. (Elsevier, 2019)Ethnopharmacology relevance Traditional herbal medicines are utilized by 27 million South Africans. Xysmalobium undulatum (Uzara) is one of the most widely used traditional medicinal plants in Southern Africa. A false ...