Now showing items 1-2 of 2

    • 2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase 

      Nel, Magdalena S.; Petzer, Anél; Petzer, Jacobus P.; Legoabe, Lesetja J. (Elsevier, 2016)
      In the present study, a series of twenty-two 2-benzylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 2-benzylidene-1-indanone derivatives ...
    • Synthesis and evaluation of 1-indanone derivatives as inhibitors of monoamine oxidase 

      Nel, Magdalena Salomina (North-West University (South Africa) , Potchefstroom Campus, 2016)
      Parkinson‘s disease (PD) is a neurodegenerative disorder characterised by the death of neurons in the substantia nigra pars compacta (SNpc) in the midbrain leading to a dopamine (DA) deficiency. This deficiency is responsible ...