Now showing items 1-3 of 3

    • C6- and C7-substituted 3,4-dihydro-2(1H)-quinolinones as inhibitors of monoamine oxidase 

      Meiring, Letitia; Petzer, Jacobus Petrus; Petzer, Anél (Thieme, 2017)
      Purpose Monoamine oxidase (MAO) inhibitors are considered to be useful therapeutic agents and isoform specific inhibitors are employed for the treatment of depression and Parkinson’s disease. MAO inhibitors are also under ...
    • Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives 

      Meiring, Letitia; Petzer, Jacobus P.; Petzer, Anél (Elsevier, 2013)
      In the present study, a series of 3,4-dihydro-2(1H)-quinolinone derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 3,4-dihydro-2(1H)- quinolinone derivatives ...
    • Monoamine oxidase inhibition by novel quinolinones 

      Meiring, Letitia (2014)
      Parkinson’s disease (PD) is an age-related neurodegenerative disorder. The degeneration of the neurons of the substantia nigra in the midbrain leads to the loss of dopamine from the striatum, which is responsible for the ...