Browsing by Subject "Absorption enhancement"
Now showing items 1-5 of 5
-
Design and evaluation of chitosan and N-trimethyl chitosan chloride microspheres for intestinal drug delivery
(North-West University, 2005)The absorption enhancing ability of chitosan, a linear polysaccharide, is mediated by protonated amino groups on the C-2 position of the molecules that induce interaction with the anionic sites on the cell membranes to ... -
Drug absorption enhancement capacities and mechanisms of action of Aloe vera gel materials
(North-West University (South Africa), Potchefstroom Campus, 2018)Oral drug delivery is one of the most preferred and user friendly routes of drug administration. Macromolecular drugs (such as peptides and proteins) generally have a poor bioavailability when administered orally. Absorption ... -
Intestinal drug absorption enhancement by Aloe vera gel and whole leaf extract: in vitro investigations into the mechanisms of action
(MDPI, 2019)The co-administration of absorption enhancing agents with macromolecular drugs (e.g., protein and peptide drugs) has been identified as a means to improve the oral bioavailability of these drugs. Absorption-enhancing agents ... -
Intestinal drug absorption enhancers: synergistic effects of combinations
(Taylor & Francis, 2008)Although many absorption enhancers have been investigated, very few are used clinically. A need exists therefore for more effective absorption enhancers. The drug-absorption-enhancing effects of combinations of N-trimethyl ... -
Paracellular drug absorption enhancement through tight junction modulation
(Taylor & Francis, 2013)Introduction: Inclusion of absorption-enhancing agents in dosage forms is one approach to improve the bioavailability of active pharmaceutical ingredients with low membrane permeability. Tight junctions are dynamic protein ...