Browsing by Subject "Absorption enhancer"
Now showing items 1-9 of 9
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Combining chemical permeation enhancers for synergistic effects
(Springer, 2016)Currently, macromolecular drugs such as proteins are mainly administered by means of injections due to their low intestinal epithelial permeability and poor stability in the gastrointestinal tract. This study ... -
Combining chemical permeation enhancers to obtain synergistic effects
(2014)The oral route of administration remains the preferred route of administrating drugs due to patient acceptance and compliance. Therapeutic proteins are currently mainly administered by means of the parenteral route because ... -
Development of a bead-in-matrix delivery system for insulin
(North-West University, 2018)The oral route remains the most convenient and popular route for drug administration. However, for therapeutic peptide drugs, parenteral administration remains the most used route of administration as the use of the oral ... -
Development of a double phase dosage form for enhanced peptide drug delivery
(2015)Parenteral administration remains the most utilised route of administration for therapeutic peptides due to low intestinal epithelial permeability. However, the most convenient and popular route of drug administration ... -
Development of micro-beads that contain functional excipients for effective oral delivery of macromolecular drugs
(North-West University, 2018)Biotechnology advancements have made it possible to produce proteins and peptides for therapeutic applications on a large scale. These peptides are mostly administered parenterally, which hampers patient compliance due to ... -
Development of vitamin C and E fixed-dose combination, multiple-unit, solid oral delivery systems
(North-West University (South-Africa). Potchefstroom Campus, 2019-05)Oral drug delivery is one of the most preferred and user-friendly routes of drug administration, however, vitamin C and vitamin E have poor and unreliable bioavailability at doses intended for anti-oxidant effects. This ... -
Excipients with specialized functions for effective drug delivery
(Taylor & Francis, 2012)Introduction: There is a growing need for the development of pharmaceutical excipients that could improve product performance and overcome the shortcomings of new drug moieties, such as their poor solubility and membrane ... -
In vitro evaluation of the cytotoxic, antibacterial and antioxidant properties of selected chitosan derivatives and melittin
(North-West University (South Africa) , Potchefstroom Campus, 2015)New excipients to improve the oral absorption of drugs are developing significantly. Polymers are used to enhance drug absorption through the gastrointestinal tract. Chitosan is a biocompatible polymer that is capable of ... -
Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride
(Taylor & Francis, 2010)The aim of this study was to evaluate the ability of TMC, with different degrees of quaternization, to increase insulin absorption in vivo following nasal and rectal administration in rats. Two batches of TMC with different ...