Now showing items 1-2 of 2

    • The design, synthesis and evaluation of aminocaffeine derivatives as inhibitors of monoamine oxidase B 

      Moraal, Christina Maria (North-West University, 2011)
      Monoamine oxidase (MAO) is responsible for dopamine catabolism in the brain and therefore is especially important in the treatment of Parkinson's disease (PD). MAO–B inhibition provides symptomatic relief by indirectly ...
    • Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase 

      Booysen, Hermanus P.; Moraal, Christina; Terre'Blanche, Gisella; Petzer, Anél; Bergh, Jacobus J.; Petzer, Jacobus P.; Booysen, Hermanus P.; Moraal, Christina; Terre'Blanche, Gisella; Petzer, Anél; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2011)
      In a recent study it was shown that 8-benzyloxycaffeine analogues act as potent reversible inhibitors of human monoamine oxidase (MAO) A and B. Although the benzyloxy side chain appears to be particularly favorable for ...