Browsing by Subject "Enzyme inhibition"
Now showing items 1-6 of 6
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Beneficial pharmacokinetic drug interactions: a tool to improve the bioavailability of poorly permeable drugs
(MDPI, 2018)Simultaneous oral intake of herbs, supplements, foods and drugs with other drug(s) may result in pharmacokinetic or pharmacodynamic interactions with the latter. Although these interactions are often associated with unwanted ... -
Discovery of catechol-O-methyltransferase inhibitors through virtual screening
(North-West University (South Africa) , Potchefstroom Campus, 2016)BACKGROUND AND RATIONALE: Parkinson’s disease (PD) is a progressive neurodegenerative disease that is caused by the death of dopaminergic neurons in the substantia nigra resulting in a loss of dopamine in the striatum. ... -
In vitro evaluation of the enzyme inhibition and membrane permeation properties of benzophenones extracted from honeybush
(North-West University (South Africa) , Potchefstroom Campus, 2016)Tea prepared from the honeybush (Cyclopia spp.) plant has become a popular beverage and has been shown to possess medicinal properties. Honeybush plants contain phytochemicals that can contribute to the prevention of certain ... -
Investigation of the monoamine oxidase inhibition properties of benzoxathiolone derivatives
(Springer, 2023)The treatment of neuropsychiatric and neurodegenerative disorders such as depression and Parkinson’s disease represent significant challenges in healthcare. Enzymes that metabolise neurotransmitter amines are important ... -
Recent developments in our understanding of the implications of traditional African medicine on drug metabolism
(Taylor & Francis, 2018)Introduction: The use of traditional herbal medicines has become increasingly popular globally, but in some countries, it is the main or sometimes even the only healthcare service available in the most rural areas. This ... -
Screening of virtual libraries for monoamine oxidase inhibitors
(2013)The traditional view of drug design is that a single drug should interact with a single molecular target. As science progressed, there was an understanding that most drugs interact with more than one target and that ...