Browsing by Subject "Reassortment"
Now showing items 1-6 of 6
-
Establishment of different plasmid only-based reverse genetics systems for the recovery of African horse sickness virus
(Elsevier, 2016)In an effort to simplify and expand the utility of African horse sickness virus (AHSV) reverse genetics, different plasmid-based reverse genetics systems were developed. Plasmids containing cDNAs corresponding to each of ... -
Investigating the role of rotavirus GS10(NSP4) and GS6(VP6) in reassortment
(North-West University (South Africa), 2023)Rotaviruses are dsRNA viruses and are the leading causative agent of severe gastroenteritis. All current licenced rotavirus vaccines contain live-attenuated strains and are capable of reassorting their genome segments ... -
Optimization of rotavirus reverse genetics and the rescue of rationally designed rotaviruses
(North-West University (South Africa), 2023)Rotaviruses are the leading cause of diarrhoea related deaths in children under the age of five, despite the availability of vaccines. The currently available rotavirus vaccines are up to 30% less effective in the developing ... -
Requirements and comparative analysis of reverse genetics for bluetongue virus (BTV) and African horse sickness virus (AHSV)
(BioMed Central, 2016)Background Bluetongue virus (BTV) and African horse sickness virus (AHSV) are distinct arthropod borne virus species in the genus Orbivirus (Reoviridae family), causing the notifiable diseases Bluetongue and African horse ... -
Sequence analysis of the whole genomes of five African human G9 rotavirus strains
(Elsevier, 2013)The G9 rotaviruses are amongst the most common global rotavirus strains causing severe childhood diarrhoea. However, the whole genomes of only a few G9 rotaviruses have been fully sequenced and characterised of which ... -
Viral replication kinetics and in vitro cytopathogenicity of parental and reassortant strains of bluetongue virus serotype 1, 6 and 8
(Elsevier, 2014)Bluetongue virus (BTV), a segmented dsRNA virus, is the causative agent of bluetongue (BT), an economically important viral haemorrhagic disease of ruminants. Bluetongue virus can exchange its genome segments in mammalian ...