Browsing by Subject "Tight junction"
Now showing items 1-3 of 3
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Development and evaluation of a double-phase multiple-unit dosage form for enhanced insulin intestinal delivery
(Bentham Science, 2018)Background: The oral route is the most preferred route of administration for selfmedication, but poor membrane permeability and pre-systemic degradation are key challenges that need to be addressed. Objective: The purpose ... -
Drug bioavailability enhancing agents of natural origin (bioenhancers) that modulate drug membrane permeation and pre-systemic metabolism
(MDPI, 2019)Many new chemical entities are discovered with high therapeutic potential, however, many of these compounds exhibit unfavorable pharmacokinetic properties due to poor solubility and/or poor membrane permeation characteristics. ... -
Paracellular drug absorption enhancement through tight junction modulation
(Taylor & Francis, 2013)Introduction: Inclusion of absorption-enhancing agents in dosage forms is one approach to improve the bioavailability of active pharmaceutical ingredients with low membrane permeability. Tight junctions are dynamic protein ...