Browsing by Author "10091130 - Malan, Linda"
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Adjusting haemoglobin values for altitude maximizes combined sensitivity and specificity to detect iron deficiency among women of reproductive age in Johannesburg, South Africa
Silubonde, Takana Mary; Baumgartner, Jeannine; Malan, Linda; Smuts, Cornelius Matheus; Ware, Lisa Jayne (MDPI, 2020)In South Africa, haemoglobin (Hb) is measured to screen for iron deficiency (ID). However, low levels of Hb are only a late stage indicator of ID. Furthermore, Hb values are generally not adjusted for altitude even though ... -
Breast milk and erythrocyte fatty acid composition of lactating women residing in a peri‑urban South African township
Siziba, Linda P.; Chimhashua, Tsitsi; Siro, Sicelosethu S.; Jacobs, Adriaan; Malan, Linda; Smuts, Cornelius M.; Baumgartner, Jeannine (Elsevier, 2020)Data on breast milk fatty acid (FA) composition in South African lactating women in relation to their FA status, as well as on potential compositional changes within feed, are limited. The aim of this study was to assess ... -
Combined deficiency of iron and (n-3) fatty acids in male rats disrupts brain monoamine metabolism and produces greater memory deficits than iron deficiency or (n-3) fatty acid deficiency alone1-3
Baumgartner, Jeannine; Smuts, Cornelius M.; Malan, Linda; Arnold, Myrtha; Yee, Benjamin K. (American Society of Nutrition (ASN), 2012)Deficiencies of iron (Fe) (ID) and (n-3) fatty acids (FA) [(n-3)FAD] may impair brain development and function through shared mechanisms. However, little is known about the potential interactions between these 2 common ... -
Determining sample size adequacy for animal model studies in nutrition research: limits and ethical challenges of ordinary power calculation procedures
Ricci, Cristian; Baumgartner, Jeannine; Malan, Linda; Smuts, Cornelius M. (Taylor & Francis, 2020)Animal models are widely used in the field of nutrition research. Scientifically and ethically sound experiments need an adequate number of experimental units. The use of 5-10 units is common, but such sample sizes can be ... -
Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial
Smuts, Cornelius M.; Matsungo, Tonderayi M.; Malan, Linda; Kruger, Herculina S.; Rothman, Marinel; Covic, Namukolo; Joosten, Karen; Lombard, Carl J.; Faber, Mieke (Oxford Univ Press, 2019)Background Evidence on the effect of small-quantity lipid-based nutrient supplements (SQ-LNSs) on early child growth and development is mixed. Objective This study assessed the effect of daily consumption of 2 different ... -
The effects of anti-inflammatory agents as host-directed adjunct treatment of tuberculosis in humans: a systematic review and meta-analysis
Hayford, Frank Ekow Atta; Dolman, Robin Claire; Nienaber, Arista; Smuts, Cornelius Mattheus; Malan, Linda; Ricci, Cristian (BMC, 2020)Background The potential role of adjunctive anti-inflammatory therapy to enhance tuberculosis (TB) treatment has recently received increasing interest. There is, therefore, a need to broadly examine current host-directed ... -
Effects of iron and n-3 fatty acid supplementation, alone and in combination, on cognition in school children: a randomized, double-blind, placebo-controlled intervention in South Africa
Baumgartner, Jeannine; Smuts, Cornelius Mattheus; Malan, Linda; Kvalsvig, Jane; Van Stuijvenberg, M.; Hurrell, Richard; Zimmermann, Michael B. (American Society for Nutrition (ASN), 2012)Background: Little is known about the combined effects of iron and n−3 (omega-3) fatty acid (FA) supplementation on cognitive performance. The provision of either DHA/EPA or iron alone in rats with combined iron and n−3 ... -
Fatty acid and micronutrient intake and status in association with allergy among pregnant urban women in South Africa
Van Zyl, I. (North-West University, 2018)Background: Allergy has become a global problem, consequently reaching epidemic proportions. Worldwide, in both developed and developing countries, the prevalence of allergic disease is rising substantially, with an estimated ... -
Four-oil intravenous lipid emulsion effect on plasma fatty acid composition, inflammatory markers and clinical outcomes in acutely ill patients: a randomised control trial (Foil fact)
Donoghue, V.; Malan, L.; Schleicher, G.K.; Spruyt, M.G.L.; Nel, D.G. (Elsevier, 2019)Background and aims Data in critically ill patients on the effect of intravenous lipid emulsions (LEs), containing omega-3 polyunsaturated fatty acids (PUFAs), in parenteral nutrition (PN) are scarce and conflicting. This ... -
In male rats with concurrent iron and (n-3) fatty acid deficiency, provision of either iron or (n-3) fatty acids alone alters monoamine metabolism and exacerbates the cognitive deficits associated with combined deficiency 1-3
Baumgartner, Jeannine; Smuts, Cornelius M.; Malan, Linda; Arnold, Myrtha; Yee, Benjamin K.; Yee, Benjamin K. (American Society of Nutrition (ASN), 2012)Concurrent deficiencies of iron (Fe) (ID) and (n-3) fatty acids [(n-3)FAD)] in rats can alter brain monoamine pathways and impair learning and memory. We examined whether repletion with Fe and DHA/EPA, alone and in ... -
Iron and a mixture of DHA and EPA supplementation, alone and in combination, affect bioactive lipid signalling and morbidity of iron deficient South African school children in a two-by-two randomised controlled trial
Malan, L.; Baumgartner, J.; Zandberg, L.; Smuts, C.M.; Calder, P. (Elsevier Sci Ltd, 2016)We recently reported that iron supplementation increased respiratory morbidity in iron deficient South African children. This increase, however, was attenuated when iron was provided in combination with a mixture of DHA/EPA. ... -
Low immune cell ARA and high plasma 12-HETE and 17-HDHA in iron-deficient South African school children with allergy
Malan, L.; Baumgartner, J.; Smuts, C.M.; Calder, P. (Elsevier, 2016)Allergy has been associated with altered fatty acid and inflammatory status. In this cross-sectional study of 321 rural iron deficient (ID) South African children (aged 6–11 years), a subsample (n=111) of children with ... -
Maternal iron-deficiency is associated with premature birth and higher birth weight despite routine antenatal iron supplementation in an urban South African setting: the NuPED prospective study
Symington, Elizabeth A.; Baumgartner, Jeannine; Malan, Linda; Ricci, Cristian; Zandberg, Lizelle; Smuts, Cornelius M. (PLoS, 2019)Background Recent studies are suggesting a U-shaped relationship between antenatal iron exposure and birth outcomes. Little is known about the iron status and associated birth outcomes of pregnant women in South Africa. ... -
Missing data imputation via the expectation-maximization algorithm can improve principal component analysis aimed at deriving biomarker profiles and dietary patterns
Malan, Linda; Smuts, Cornelius M.; Baumgartner, Jeannine; Ricci, Cristian (Elsevier, 2020)Principal component analysis (PCA) is a popular statistical tool. However, despite numerous advantages, the good practice of imputing missing data before PCA is not common. In the present work, we evaluated the hypothesis ... -
n-3 Long-chain PUFAs reduce respiratory morbidity caused by iron supplementation in iron-deficient South African schoolchildren: a randomized, double-blind, placebo-controlled intervention
Malan, Linda; Baumgartner, Jeannine; Calder, Philip; Zimmermann, Michael; Smuts, Cornelius Mattheus (American Society for Nutrition, 2015)ABSTRACT Background: Although iron supplementation in malaria–free areas "mostly reduces infectious morbidity, it can sometimes increase morbidity" from infections as a result of the dependence of pathogenic ... -
Nutrition during pregnancy and early development (NuPED) in urban South Africa: a study protocol for a prospective cohort
Symington, Elizabeth A.; Baumgartner, Jeannine; Malan, Linda; Zandberg, Lizelle; Ricci, Cristian; Smuts, Cornelius M. (BioMed Central, 2018)Background Adequate nutrition during pregnancy is important to ensure optimal birth outcomes, maternal health and offspring development. However, little is known about the dietary intake and nutritional status of pregnant ... -
Overweight impairs efficacy of iron supplementation in iron-deficient South African children: a randomized controlled intervention
Baumgartner, J.; Smuts, C.M.; Aeberli, I.; Malan, L.; Tjalsma, H.; Zimmermann, M.B. (Nature Publishing Group, 2013)BACKGROUND: Many countries in the nutrition transition have high rates of iron deficiency (ID) and overweight (OW). ID is more common in OW children; this may be due to adiposity-related inflammation reducing iron ... -
Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children
Chimhashu, Tsitsi; Malan, Linda; Baumgartner, Jeannine; Smuts, Cornelius M.; Van Jaarsveld, Paul J. (Cambridge Univ Press, 2018)Zn status may affect fatty acid (FA) metabolism because it acts as a cofactor in FA desaturase and elongase enzymes. Zn supplementation affects the FA desaturases of Zn-deficient rats, but whether this occurs in humans ... -
Sodium content of foodstuffs included in the sodium reduction regulation of South Africa
Swanepoel, Bianca; Malan, Linda; Myburgh, P. Herman; Schutte, Aletta E.; Wentzel-Viljoen, Edelweiss (Elsevier, 2017)As a first step in combating the high hypertension rate in South Africa, the Government has recently implemented a mandatory regulation (R.214) pertaining to the sodium content of foodstuffs with targets for 2016 and 2019. ...