Browsing by Author "12791733 - Van Reenen, Mari"
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The 1H-NMR-based metabolite profile of acute alcohol consumption: a metabolomics intervention study
Irwin, Cindy; Van Reenen, Mari; Mason, Shayne; Mienie, Lodewyk J.; Westerhuis, Johan A.; Reinecke, Carolus J. (PLoS, 2018)Metabolomics studies of disease conditions related to chronic alcohol consumption provide compelling evidence of several perturbed metabolic pathways underlying the pathophysiology of alcoholism. The objective of the present ... -
Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge
Erasmus, Elardus; Van Reenen, Mari; Vorster, B. Chris; Reinecke, Carolus J.; Steffens, Francois E. (Public Library of Science, 2019)Chronic fatigue, in its various manifestations, frequently co-occur with pain, sleep disturbances and depression and is a non-communicable condition which is rapidly becoming endemic worldwide. However, it is handicapped ... -
Contribution towards a metabolite profile of the detoxification of benzoic acid through glycine conjugation: an intervention study
Irwin, Cindy; Van Reenen, Mari; Mason, Shayne; Mienie, Lodewyk J.; Reinecke, Carolus J.; Westerhuis, Johan A. (PLoS, 2016)Benzoic acid is widely used as a preservative in food products and is detoxified in humans through glycine conjugation. Different viewpoints prevail on the physiological significance of the glycine conjugation reaction ... -
A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls
Malatji, Bontle G.; Mason, Shayne; Van Reenen, Mari; Reinecke, Carolus J.; Meyer, Helgard (BioMed Central, 2017)Background: Fibromyalgia syndrome (FMS) is a chronic pain syndrome. A plausible pathogenesis of the disease is uncertain and the pursuit of measurable biomarkers for objective identification of affected individuals is a ... -
Ethnic identification as contributor to the development of moral identity in child-headed households
Pretorius, Jacqueline; Jacobs, Susanne; Van Reenen, Marie (Taylor & Francis, 2013)This study explored whether ethnic membership was a core construct in the moral identity development of adolescents in Zulu child-headed households. A convenience sample of 60 participants (31 male and 29 female) were ... -
Gas chromatography-mass spectrometry profiles of urinary organic acids in healthy captive cheetahs ( Acinonyx jubatus )
Tordiffe, Adrian Stephen Wolferstan; Van Reenen, Mari; Mienie, Lodewyk Jacobus; Reyers, Fred (Elsevier, 2017)In captivity, cheetahs (Acinonyx jubatus) frequently suffer from several unusual chronic diseases that rarely occur in their free-ranging counterparts. In order to develop a better understanding of their metabolism and ... -
The GC-MS metabolomics signature in patients with fibromyalgia syndrome directs to dysbiosis as an aspect contributing factor of FMS pathophysiology
Malatji, Bontle G.; Mason, Shayne; Mienie, Lodewyk J.; Van Reenen, Mari; Reinecke, Carolus J. (Springer, 2019)Introduction Fibromyalgia syndrome (FMS) is a chronic pain syndrome. Previous analyses of untargeted metabolomics data indicated altered metabolic profile in FMS patients. Objectives We report a semi-targeted explorative ... -
GC-MS-based urinary organic acid profiling reveals multiple dysregulated metabolic pathways following experimental acute alcohol consumption
Irwin, Cindy; Mienie, Lodewyk J.; Mason, Shayne; Van Reenen, Mari; Reinecke, Carolus J. (Nature, 2018)Metabolomics studies of diseases associated with chronic alcohol consumption provide compelling evidence of several perturbed metabolic pathways. Moreover, the holistic approach of such studies gives insights into the ... -
A laboratory approach for characterizing chronic fatigue: what does metabolomics tell us?
Erasmus, Elardus; Mason, Shayne; Van Reenen, Mari; Vorster, B. Chris; Reinecke, Carolus J. (Springer, 2019)Introduction Manifestations of fatigue range from chronic fatigue up to a severe syndrome and myalgic encephalomyelitis. Fatigue grossly affects the functional status and quality of life of affected individuals, prompting ... -
Metabolic characterization of tuberculous meningitis in a South African paediatric population using 1H NMR metabolomics
Van Zyl, Christiaan De Wet; Loots, Du Toit; Van Reenen, Mari; Mason, Shayne; Solomons, Regan (Elsevier, 2020)Objective To better characterize the cerebrospinal fluid (CSF) metabolic profile of tuberculous meningitis (TBM) cases using a South African paediatric cohort. Methods 1H NMR metabolomics was used to analyse the CSF ... -
Metabolic risks at birth of neonates exposed in utero to HIV-antiretroviral therapy relative to unexposed neonates: an NMR metabolomics study of cord blood
Moutloatse, Gontse P.; Van Reenen, Mari; Mason, Shayne; Reinecke, Carools J.; Bunders, Madeleine J. (Springer, 2016)Introduction Antiretroviral therapy (ART) for HIV-infected pregnant women is highly effective in preventing mother-to-child transmission (PMTCT) of the virus, but deleterious metabolic and mitochondrial observations in ... -
Metabolic risks of neonates at birth following in utero exposure to HIV-ART: the amino acid profile of cord blood
Moutloatse, Gontse P.; Lindeque, Zander; Van Reenen, Mari; Reinecke, Carolus J.; Schoeman, Johannes C. (Springer, 2017)Introduction Untargeted metabolomics of cord blood indicated that antiretroviral therapy to HIV-infected mothers (HIV-ART) did not compromise the exposed neonates with regard to the stress of neonatal hypoglycaemia at ... -
Metabolomics variable selection and classification in the presence of observations below the detection limit using an extension of ERp
Van Reenen, Mari; Westerhuis, Johan A.; Reinecke, Carolus J.; Venter, J. Hendrik (BioMed Central, 2017)Background ERp is a variable selection and classification method for metabolomics data. ERp uses minimized classification error rates, based on data from a control and experimental group, to test the null hypothesis of ... -
Metallothionein 1 overexpression does not protect against mitochondrial disease pathology in Ndufs4 knockout mice
Miller, Hayley Christy; Louw, Roan; Mereis, Michelle; Venter, Gerda; Boshoff, John-Drew; Mienie, Liesel; Van Reenen, Mari; Venter, Marianne; Lindeque, Jeremie Zander; Van der Westhuizen, Francois Hendrikus (Springer, 2021)Mitochondrial diseases (MD), such as Leigh syndrome (LS), present with severe neurological and muscular phenotypes in patients, but have no known cure and limited treatment options. Based on their neuroprotective effects ... -
Mycobacterium tuberculosis curli pili (MTP) deficiency is associated with alterations in cell wall biogenesis, fatty acid metabolism and amino acid synthesis
Ashokcoomar, S.; Loots, D.T.; Beukes, D.; Van Reenen, M.; Reedoy, K.S. (Springer, 2020)Introduction In an effort to find alternative therapeutic interventions to combat tuberculosis, a better understanding of the pathophysiology of Mycobacterium tuberculosis is required. The Mycobacterium tuberculosis curli ... -
Mycobacterium tuberculosis curli pili (MTP) is associated with significant host metabolic pathways in an A549 epithelial cell infection model and contributes to the pathogenicity of Mycobacterium tuberculosis
Reedoy, K.S.; Loots, D.T.; Beukes, D.; Van Reenen, M.; Pillay, B. (Springer, 2020)Introduction A clear understanding of the metabolome of Mycobacterium tuberculosis and its target host cell during infection is fundamental for the development of novel diagnostic tools, effective drugs and vaccines ... -
Mycobacterium tuberculosis curli pili (MTP) is associated with significant host metabolic pathways in an A549 epithelial cell infection model and contributes to the pathogenicity of Mycobacterium tuberculosis
Reedoy, K.S.; Loots, D.T.; Beukes, D.; Van Reenen, M.; Pillay, B. (Springer, 2020)Introduction A clear understanding of the metabolome of Mycobacterium tuberculosis and its target host cell during infection is fundamental for the development of novel diagnostic tools, effective drugs and vaccines ... -
Predicting tuberculosis treatment outcome using metabolomics
Luies, Laneke; Van Reenen, Mari; Loots, Du Toit; Ronacher, Katharina; Walzl, Gerhard (Future Medicine, 2017)Aim: Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and ... -
Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice
Parihar, S.P.; Loots, D.T.; Beukes, D.; Van Reenen, M.; Ozturk, M. (Nature, 2018)We previously demonstrated that protein kinase C-δ (PKCδ) is critical for immunity against Listeria monocytogenes, Leishmania major, and Candida albicans infection in mice. However, the functional relevance of PKCδ during ... -
Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice. ERRATA
Parihar, S.P.; Loots, D.T.; Beukes, D.; Van Reenen, M.; Ozturk, M. (Nature, 2018)