Browsing by Author "13168185 - Levanets, Oksana"
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Aberrant synthesis of ATP synthase resulting from a novel deletion in mitochondrial DNA in an African patient with progressive external ophthalmoplegia
Van der Westhuizen, Francois H.; Levanets, Oksana; Meissner-Roloff, Madelein; Louw, Roan; Smet, Joél (Springer, 2010)A young, adult, African male patient presented with progressive proximal muscle weakness, external ophthalmoplegia and ptosis, as well as cardiac conduction abnormalities resembling Kearns–Sayre syndrome (KSS). Magnetic ... -
The involvement of metallothioneins in mitochondrial function and disease
Lindeque, J.Z.; Levanets, O.; Louw, R.; Van der Westhuizen, F.H. (Bentham Science, 2010)Mitochondrial oxidative phosphorylation deficiency is accompanied by various down-stream, adaptive responses which play a key role in the varied phenotypes observed when mitochondrial dysfunction occurs. These responses ... -
Mitochondrial DNA replication and OXPHOS gene transcription show varied responsiveness to Rieske protein knockdown in 143B cells
Levanets, Oksana; Reinecke, Fimmie; Louw, Roan; Pretorius, Pieter J.; Du Plessis, Lissinda H.; Van der Westhuizen, Francois H. (Elsevier, 2011)Genetic, biochemical and phenotypic diversity is a hallmark of OXPHOS deficiencies. Among the responses frequently reported for these deficiencies is differential expression of several genes involved in mitochondrial ... -
Rapid cell lysis and DNA capture in a lysis microreactor
Grobler, Anne; Levanets, Oksana; Whitney, Scott; Booth, Christine; Viljoen, Hendrik (Elsevier, 2012)In clinical diagnostics, the detection and identification of bacterial organisms based on the analysis of their nucleic acids require cell lysis and DNA extraction from clinical samples. A lysis microreactor (LMR) has been ...