Browsing by Author "16951484 - Zeevaart, Jan Rijn"
Now showing items 1-20 of 29
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68Ga-NOTA-functionalized ubiquicidin: cytotoxicity, biodistribution, radiation dosimetry, and first-in-human PET/CT imaging of infections
Ebenhan, Thomas; Zeevaart, Jan R.; Sathekge, Mike M.; Lengana, Thabo; Koole, Michel (Society of Nuclear Medicine and Molecular Imaging, 2018)Ubiquicidin is an antimicrobial peptide with great potential for nuclear imaging of infectious diseases, as its cationic-rich fragment TGRAKRRMQYNRR (UBI) has been functionalized with NOTA to allow complexation to 68Ga ... -
99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles
Mandiwana, Vusani; Grobler, Anne; Zeevaart, Jan Rijn; Kalombo, Lonji (Elsevier, 2018)The aim of this study was to establish the in vivo uptake and tissue distribution of 99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive 99mTc-MDP encapsulated into SLNs was administered ... -
Bioaccumulation and subchronic toxicity of 14 nm gold nanoparticles in rats
Rambanapasi, Clinton; Zeevaart, Jan Rijn; Buntting, Hylton; Bester, Cornelius; Hayeshi, Rose; Grobler, Anne (MDPI, 2016)Colloidal suspensions of 14 nm gold nanoparticles (AuNPs) were repeatedly administered intravenously at three dose levels (0.9, 9 and 90 µg) to male Sprague Dawley rats weekly for 7 weeks, followed by a 14-day washout ... -
Biodistribution (as determined by the radiolabelled equivalent) of a gold(III) bis(pyrrolide-imine) Schiff base complex: a potential chemotherapeutic
Akerman, Matthew P.; Bester, Cornelius J.; Zeevaart, Jan Rijn; Munro, Orde Q.; Mongane, Modisenyane (Wiley, 2013)The biodistribution of an N2N2 0 tetradentate gold(III) chelate, which is known to be cytotoxic towards a range of human cancer cell lines, was determined by a radiolabelled equivalent of the compound. The 198Au-labelled ... -
Biodistribution and dosimetry of 195mPt-cisplatin in normal volunteers
Sathekge, M.; Zeevaart, J.R.; Wagener, J.; Smith, S.V.; Soni, N. (Schattauer, 2013)195mPt-cisplatin is regarded as a promising imaging agent for optimizing dosage in patients receiving cisplatin chemotherapy. We investigated the whole-body distribution and radiation dosimetry of 195mPt-cisplatin in ... -
Biodistribution and pharmacokinetics of I-131 labelled 4- Iodophenylacetic acid
Zeevaart, Jan Rijn; Szucs, Zoltan; Pulker, Tamsyn; Sello, Thato; Bracher, Jacqueline (Bentham Science, 2012)Abstract: Phenylacetate has been reported to have a potent anti-proliferative and anti-differentiating effect in haematological malignancies and in solid tumours at non-toxic concentrations. This study is a preliminary ... -
Biodistribution of a potential chemotherapeutic, dinuclearbisphosphinogold(I) dithiocarbamate, as determined by its 198Au radiolabelled analogue
Kriel, Frederik H.; Bester, Cornelius J.; Zeevaart, Jan Rijn; Szucs, Zoltan; Van Staden, Johan A. (Springer, 2015)Dinuclearbisphosphinogold(I) dithiocarbamato, BPDTC, was previously found to have antitumour activity in vitro. 198Au radiolabelled BPDTC (radiochemical yield of 70 ± 6 % and radiochemical purity of[95 %) was used to ... -
Carbon-14 radiolabeling and in vivo biodistribution of a potential anti-TB compound
Sonopo, Molahlehi S.; Zeevaart, Jan R.; Venter, Kobus; Boyle, Grant; Winks, Susan (Wiley, 2015)A potential anti-TB compound bearing a nitroimidazole moiety from iThemba Pharmaceuticals TB chemical library exhibits promising in vitro activity in the microplate almar blue assay (MABA) with a minimum inhibitory ... -
Carbon-14 radiolabelling and tissue distribution evaluation of a potential anti-TB compound
Sonopo, Molahlehi S.; Zeevaart, Jan R.; Venter, Kobus; Winks, Susan; Marjanovic-Painter, Biljana (Wiley, 2016)This paper describes a five-step synthesis of a carbon-14-labelled pyrazole compound (11). A total of 2.96 MBq of 11 was obtained with the specific activity of 2242.4 MBq/mmol. The radiochemical purity was >99%, and the ... -
Carbon‐14 radiolabeling and tissue distribution evaluation of MMV390048
Sonopo, Molahlehi S.; Zeevaart, Jan R.; Pillay, Adushan; Chibale, Kelly; Marjanovic-Painter, Biljana (Wiley, 2016)The antimalarial compound MMV390048 ([14C]-11) was labeled with carbon-14 isotope via a 3-step synthesis. It was obtained in a 15.5% radiochemical overall yield from carbon-14 labeled methyl iodide with a radiochemical ... -
Comparison of DOTA and NODAGA as chelates for 68Ga-labelled CDP1 as novel infection PET imaging agents
Mdlophane, A.H.; Zeevaart, J.R.; Ebenhan, T.; Marjanovic-Painter, B.; Govender, T. (Springer, 2019)The cathelicidin-derived peptide (CDP1) is a human antimicrobial peptide that preferentially targets bacterial membranes in response to infection. CDP1 was functionalised with NODAGA and DOTA for complexation with gallium-68 ... -
Complexation studies of 177Lu with ethylenediaminetetramethylene phosphonic acid (EDTMP) as a bone pain palliative therapeutic radiopharmaceutical
Sepini, Lebogang; Zeevaart, Jan Rijn; Jansen, David; Jarvis, Neil (Elsevier, 2016)Therapeutic radiopharmaceuticals for bone pain palliation play an important role in providing quality of life for cancer patients with metastatic bone cancer. There is currently interest in using 177Lu in many radiopharm ... -
Development of a single vial kit solution for radiolabeling of 68Ga-DKFZ-PSMA-11 and its performance in prostate cancer patients
Ebenhan, Thomas; Zeevaart, Jan Rijn; Vorster, Mariza; Marjanovic-Painter, Biljana; Wagener, Judith (MDPI, 2015)Prostate-specific membrane antigen (PSMA), a type II glycoprotein, is highly expressed in almost all prostate cancers. By playing such a universal role in the disease, PSMA provides a target for diagnostic imaging of ... -
Dual radiolabeling as a technique to track nanocarriers: the case of gold nanoparticles
Rambanapasi, Clinton; Barnard, Nicola; Grobler, Anne; Buntting, Hilton; Jordaan, Anine; Steyn, Hendrik; Zeevaart, Jan Rijn (MDPI, 2015)Gold nanoparticles (AuNPs) have shown great potential for use in nanomedicine and nanotechnologies due to their ease of synthesis and functionalization. However, their apparent biocompatibility and biodistribution is still ... -
Establishment of a Zr(IV) blood plasma model
Basinyi, T.V. (North-West University (South Africa), 2016)This study was carried out in an effort to verify ⁸⁹Zr as a new safe and effective nuclide for immuno-PET imaging. In recent years, immuno-PET imaging has been of increasing importance in cancer diagnostics due to its ... -
Evaluation of a flexible NOTA-RGD kit solution using Gallium-68 from different 68Ge/ 68Ga-generators: pharmacokinetics and biodistribution in nonhuman primates and demonstration of solitary pulmonary nodule imaging in humans
Ebenhan, Thomas; Schoeman, Isabel; Grobler, Anne; Zeevaart, Jan Rijn; Rossouw, Daniel D. (Springer, 2016)Purpose: Radiopharmaceuticals containing the motive tripeptide arginyl-glycyl-asparatic acid (RGD) are known to target ανβ3 integrins during tumor angiogenesis. A more generic kit radiolabeling procedure accommodating ... -
In silico modelling in the development of novel radiolabelled peptide probes
Kleynhans, Janke; Cloete, Theunis; Zeevaart, Jan Rijn; Kruger, Hendrik Gerhardus; Ebenhan, Thomas (Bentham Science, 2020)This review describes the usefulness of in silico design approaches in the design of new radiopharmaceuticals, especially peptide-based radiotracers (including peptidomimetics). Although not part of the standard arsenal ... -
In vivo evaluation of acute intravenous toxicity of a [Ga-68]Ga-PSMA-11-microemulsion
Mandiwana, Vusani; Hayeshi, Rose; Zeevaart, Jan Rijn; Kalombo, Lonji M.; Labuschagne, Philip (Elsevier, 2020)Microemulsions (MEs) are reported to improve the efficacy of a drug, minimise side effects and toxicity of the encapsulated compound. MEs are hypothesized to aid in making the encapsulated compound, which has been incorporated ... -
Molecular imaging of a zirconium-89 labeled antibody targeting Plasmodium falciparum–infected human erythrocytes
Duvenhage, Janie; Zeevaart, Jan Rijn; Ebenhan, Thomas; Garny, Seike; Hernández González, Ignacio (Springer, 2020)Purpose Nuclear imaging is an important preclinical research tool to study infectious diseases in vivo and could be extended to investigate complex aspects of malaria infections. As such, we report for the first time ... -
Non-oncological applications of RGD-based single-photon emission tomography and positron emission tomography agents
Ebenhan, Thomas; Zeevaart, Jan Rijn; Kleynhans, Janke; Jeong, Jae Min; Sathekge, Mike (Springer, 2020)Introduction Non-invasive imaging techniques (especially single-photon emission tomography and positron emission tomography) apply several RGD-based imaging ligands developed during a vast number of preclinical and clinical ...