Browsing by Author "21247250 - Möller Wolmarans, Marisa"
Now showing items 1-20 of 22
-
Bio-behavioural studies into the antidepressant and antipsychotic-like effects of Garcinia mangostana Linn extract and alpha-mangostin as adjunctive-or mono-therapy in a rodent model of schizophrenia
Harvey, B.H.; Möller, M.; Lötter, J.; Dean, O.; Berk, M. (Wiley, 2019)Introduction: Garcinia mangostana Linn (GML) or mangosteen has anti-inflammatory, antioxidant and neuroprotective actions. Its bioactive constituents, α- , β- , and γ- mangostin also inhibit cAMP ... -
Coping facilitated troponin T increases and hypo-responsivity in the copeptin-HPA-axis during acute mental stress in a black cohort: the SABPA study
Myburgh, Catharina Elizabeth; Malan, Leoné; Möller, Marisa; Steyn, Faans; Malan, Nicolaas Theodor (Elsevier, 2019)Background Defensive coping (DefS) was associated with a vulnerable cardiovascular profile in blacks. The copeptin/vasopressin system is a manifestation of hypothalamic-pituitary-adrenal-axis activity and may act as an ... -
Coping, copeptin and cardiac stress: the SABPA study
Myburgh, Catharina Elizabeth (North-West University (South-Africa). Potchefstroom Campus, 2019-05)Coping met emosionele stres kan óf effektief wees vir die neutralisering van stres óf dit kan negatiewe kardiovaskulêre uitkomste fasiliteer. Verdedigende-coping (DefS) en sosiale ondersteunings-coping is op effektiewe ... -
Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: the SABPA study
Möller, Marisa; Malan, Leoné; Mels, Carina M.C.; Malan, Nico T.; Magnusson, Martin (Wiley, 2017)Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative ... -
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma
Möller, Marisa; Du Preez, Jan L.; Harvey, Brian H. (Elsevier, 2012)It is highly beneficial to monitor the activity of the kynurenine pathway in a large series of samples with high accuracy and reliability in a single experimental protocol. We have developed a rapid specific solid-phase ... -
Efavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in rats
Möller, Marisa; Fourie, Jaco; Harvey, Brian H. (Nature, 2018)Efavirenz is abused in a cannabis-containing mixture known as Nyaope. The addictive-like effects of efavirenz (5, 10 and 20 mg/kg) was explored using conditioned place preference (CPP) in rats following sub-acute exposure ... -
The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical n-methyl-d-aspartate and d1 receptor binding in rats
Toua, C.; Brand, L.; Möller, M.; Harvey, B.H.; Emsley, R.A. (Elsevier, 2010)Glutamate and dopamine disturbances are implicated in frontal cortical dysfunction in schizophrenia. Little, however, is known about the nature of dopamine D1 and N-methyl-d-aspartate (NMDA) receptor interactions in the ... -
Exploring a gene-x-environment model of treatment resistant depression: behavioural studies and response to fluoxetine treatment
Mncube, K.; Möller-Wolmarans, M.; Harvey, B.H. (Elsevier, 2019)Background: Major depression with psychotic features presents with severe depressed mood and psychosis in the form of nihilistic-type delusions and hallucinations, and is known to be resistant to antidepressant monotherapy ... -
Garcinia mangostana Linn displays antidepressant-like and pro-cognitive effects in a genetic animal model of depression: a bio-behavioral study in the Flinders Sensitive Line rat
Oberholzer, Inge; Möller, Marisa; Harvey, Brian H.; Holland, Brendan; Dean, Olivia M. (Springer, 2018)There is abundant evidence for both disorganized redox balance and cognitive deficits in major depressive disorder (MDD). Garcinia mangostana Linn (GM) has anti-oxidant activity. We studied the antidepressant-like and ... -
Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
Möller, Marisa; Du Preez, Jan L.; Harvey, Brian H.; Emsley, Robin (Elsevier, 2011)Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR ... -
Late-life effects of chronic methamphetamine exposure during puberty on behaviour and corticostriatal mono-amines in social isolation-reared rats
Strauss, L.; Brink, C.B.; Möller, M.; Stein, D.J.; Harvey, B.H. (Karger, 2014)Chronic methamphetamine (MA) abuse results in an acute psychosis indistinguishable from paranoid schizophrenia. However, less is known of the interaction between MA use and environmental insults, and how this contributes ... -
N-acetyl cysteine as therapeutic intervention in a “two-hit” model of maternal inflammation and post-natal methamphetamine exposure
Möller, M.; Swanepoel, T.; Harvey, B.; Dean, O.; Berk, M. (Elsevier, 2016)Schizophrenia is a severe neurodegenerative, pro- gressive degenerative illness, prevalent in 0.5−1% of the world population. It is causally associated with a genetic aspect as well as early-life environmental stress. ... -
N-acetyl cysteine reverses bio-behavioural changes induced by prenatal inflammation, adolescent methamphetamine exposure and combined challenges
Swanepoel, Twanette; Möller, Marisa; Harvey, Brian Herbert (Springer, 2018)Rationale Schizophrenia is associated with prenatal inflammation and/or postnatal stressors such as drug abuse, resulting in immune-redox dysfunction. Antioxidants may offer therapeutic benefits. Objectives The objective ... -
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
Möller, Marisa; Du Preez, Jan L.; Viljoen, Francois P.; Harvey, Brian H.; Berk, Michael (Springer, 2013)Schizophrenia is causally associated with early-life environmental stress, implicating oxidative stress in its pathophysiology. N-acetyl cysteine (NAC), a glutathione precursor and antioxidant, is emerging as a useful ... -
Neurodevelopmental animal models reveal the convergent role of neurotransmitter systems, inflammation, and oxidative stress as biomarkers of schizophrenia: implications for novel drug development
Möller, M.; Swanepoel, T.; Harvey, B.H. (ACS, 2015)Schizophrenia is a life altering disease with a complex etiology and pathophysiology, and although antipsychotics are valuable in treating the disorder, certain symptoms and/or sufferers remain resistant to treatment. ... -
A review of biomarkers in mood and psychotic disorders: a dissection of clinical vs. preclinical correlates
Brand, Sarel J.; Möller, Marisa; Harvey, Brian H. (Bentham Science, 2015)Despite significant research efforts aimed at understanding the neurobiological underpinnings of mood (depression, bipolar disorder) and psychotic disorders, the diagnosis and evaluation of treatment of these disorders are ... -
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment
Möller, Marisa; Du Preez, Jan L.; Harvey, Brian H.; Emsley, Robin (Elsevier, 2012)Schizophrenia is associated with increased oxidative stress, although the source of this redox disequilibrium requires further study. Altered tryptophan metabolism has been described in schizophrenia, possibly linked to ... -
Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
Möller, Marisa; Du Preez, Jan L.; Viljoen, Francois P.; Harvey, Brian H.; Berk, Michael; Emsley, Robin (Elsevier, 2013)Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine release . N-acetyl cysteine ... -
Social isolation rearing-induced anxiety and response to agomelatine in male and female rats: role of corticosterone, oxytocin, and vasopressin
Harvey, Brian H.; Regenass, Wilmie; Dreyer, Walter; Möller, Marisa (Sage, 2019)Background: The chronobiotic antidepressant, agomelatine, acts via re-entrainment of circadian rhythms. Earlier work has demonstrated late-life anxiety and reduced corticosterone in post-weaning social isolation reared ... -
Studies into the anxiolytic actions of agomelatine in social isolation reared rats: role of corticosterone and sex
Regenass, Wilmie; Möller, Marisa; Harvey, Brian H. (Sage, 2018)Anxiety disorders are severely disabling, while current pharmacological treatments are complicated by delayed onset, low remission rates and side-effects. Sex is also noted to contribute towards illness severity and treatment ...