Browsing by Subject "Antimicrobial peptides"
Now showing items 1-5 of 5
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Antimicrobial peptides: the Achilles’ heel of antibiotic resistance?
(Springer, 2018)Antibiotic resistance is an imminent threat to the effective treatment of bacterial infections, and alternative antibiotic strategies are urgently required. The golden epoch of antibiotics is coming to an end, and the ... -
Comparison of DOTA and NODAGA as chelates for 68Ga-labelled CDP1 as novel infection PET imaging agents
(Springer, 2019)The cathelicidin-derived peptide (CDP1) is a human antimicrobial peptide that preferentially targets bacterial membranes in response to infection. CDP1 was functionalised with NODAGA and DOTA for complexation with gallium-68 ... -
An in vitro evaluation of the antibacterial and anticancer properties of the antimicrobial peptide nisin Z
(North-West University (South Africa), Potchefstroom Campus, 2018)The rise in antibiotic resistance and the lack of the development of new antibiotics poses a considerable threat to human health. This is especially of concern in individuals who are immune-compromised (due to immunosuppressive ... -
Ion selectivity and membrane potential effects of two scorpion pore-forming peptides
(North-West University, 2005)Parabutoporin (PP) and opistoporin 1 (OP1) are cation, a-helical antimicrobial peptides isolated from the southern African scorpion species, Parabuthus schlechteri and Opistophthalmus carinatus, respectively. Along with ... -
Mechanism of in vitro cytotoxicity of antimicrobial peptides in combination with stabilizing excipients
(North-West University, Potchefstroom Campus, 2018)Emerging antibiotic resistance poses a critical public health threat, particularly the alarming increase of resistant bacteria commonly associated with gastrointestinal (GI) infections. Antimicrobial peptides (AMPs) are a ...