Browsing by Subject "Bioavailability"
Now showing items 1-10 of 18
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The association between black tea consumption and iron status of African women in the North West Province : THUSA study
(North-West University, 2005)Motivation: A variety of factors including food shortage, poor hygiene and low education levels affects the nutritional status of black women. Women also have a high risk for the development of iron deficiency because ... -
Beneficial pharmacokinetic drug interactions: a tool to improve the bioavailability of poorly permeable drugs
(MDPI, 2018)Simultaneous oral intake of herbs, supplements, foods and drugs with other drug(s) may result in pharmacokinetic or pharmacodynamic interactions with the latter. Although these interactions are often associated with unwanted ... -
A clinical investigation into the bioavailability of a peroral cannabinoid-Pheroid® formulation
(North-West University (South-Africa), 2020)The therapeutic advantages of pure Cannabidiol (CBD), a phytocannabinoid isolated from the Cannabis sativa L. plant, are emphasised by the growing use of CBD in numerous conditions ranging from supplementary to the treatment ... -
Development and formulation of an intranasal dosage form for cyclizine hydrochloride
(North-West University, 2004)A comprehensive review of the nasal route of administration, in particular the nasal drug delivery system has been presented. The physicochemical properties, mode of action and pharmacology of H1-receptor antagonists, in ... -
The effect of Pheroid® technology on the bioavailability of artemisone in primates
(2014)Malaria is one the world’s most devastating diseases. Several classes of drugs are used to treat malaria. Artemisinin combination therapy is the first line treatment of uncomplicated malaria. The artemisinin derivative, ... -
Efficacy enhancement of the antimalarial drugs, mefloquine and artesunate, with PheroidTM technology
(North-West University, 2010)Malaria is currently one of the most imperative parasitic diseases in developing countries. Artesunate has a short half-life, low aqueous solubility and resultant poor and erratic absorption upon oral administration, which ... -
Immobilization and phytotoxicity reduction of heavy metals in serpentine soil using biochar
(Springer, 2015)Purpose: Serpentine soils derived from ultramafic rocks release elevated concentrations of toxic heavy metals into the environment. Hence, crop plants cultivated in or adjacent to serpentine soil may experience reduced ... -
The impact of PheroidTM technology on the bioavailability and efficacy of anti-tuberculosis drugs in an animal model
(North-West University, 2009)Tuberculosis (TB) is a worldwide pandemic with vast challenges in the fight against the disease. Challenges include the long and tedious treatment regimens and chemotherapy with adverse side effects. One approach in ... -
In vivo efficacy and bioavailability of lumefantrine: evaluating the application of Pheroid technology
(Elsevier, 2015)The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is typically limited by the dissolution rate in the gastro-intestinal tract, resulting in erratic absorption and highly variable ... -
Influence of carbon nanotubes on the bioavailability of fluoranthene
(Wiley, 2015)Concurrent with the increase in the use of carbon nanotubes (CNTs) in society is the rise of their introduction into the environment. Carbon nanotubes cause adverse effects themselves, and they have the potential to adsorb ...