Browsing by Author "Brand, Sarel Jacobus"
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Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression. I. Bio-behavioural validation and response to imipramine
Brand, Sarel Jacobus; Harvey, Brian Herbert (Cambridge Univ Press, 2017)Co-morbid depression with post-traumatic stress disorder (PTSD) is often treatment resistant. In developing a preclinical model of treatment-resistant depression (TRD), we combined animal models of depression and PTSD to ... -
Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression. II. Response to antidepressant augmentation strategies
Brand, Sarel Jacobus; Harvey, Brian Herbert (Cambridge Univ Press, 2017)Post-traumatic stress disorder (PTSD) displays high co-morbidity with major depression and treatment-resistant depression (TRD). Earlier work demonstrated exaggerated depressive-like symptoms in a gene×environment model ... -
An investigation into the antidepressant–like profile of pioglitazone in a genetic rat model of depression
Brand, Sarel Jacobus (North-West University, 2011)Major depression is a highly prevalent mood disorder with chronic debilitating effects. Additional to a rising rate in incidence, depression is highly co–morbid with other psychiatric disorders, but also chronic cardiometabolic ...