Browsing by Author "Brits, Marius"
Now showing items 1-6 of 6
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Characterisation of polymorphic, pseudopolymorphic and amorphous forms of roxithromycin
Du Plessis, Carine (North-West University, 2004)Roxithromycin is a relatively new, semisynthetic, macrolide antibiotic and an ether oxime derivative of erythromycin A, consisting of a 14-membered, macrocyclic, lactone ring. Roxithnrmycin has proven clinical efficacy in ... -
Characterization of polymorph transformations that decrease the stability of tablets containing the who essential drug mebendazole
Brits, Marius; Liebenberg, Wilna; De Villiers, Melgardt M. (Elsevier, 2010)This study investigated the influence of moisture and heat on the stability of mebendazole polymorph C in tablets. The polymorphic forms of mebendazole display significant differences in solubility and therapeutic efficacy ... -
The discriminatory ability of analytical quality control test methods : a comparison of test results from different international monographs of quinine sulfate tablets
Britz, Chantal (2013)Malaria is a parasitic disease claiming one million lives worldwide annually. Unfortunately, malaria-endemic countries in need of good quality medicines are also overwhelmed with counterfeit or substandard medicine. This ... -
The risk of recrystallization: changes to the toxicity and morphology of pyrimethamine
Perold, Zak; Brits, Marius; Caira, Mino R. (Canadian Society for Pharmaceutical Sciences, 2014)PURPOSE. Pyrimethamine, an anti-malarial agent known to exhibit solid state polymorphism, may be purified by means of recrystallization. Recrystallization may alter the solid state chemistry of pharmaceuticals, which may ... -
Solid-state properties of pharmaceuticals
Brits, Marius (North-West University, 2008)The complexity of polymorphic interconversions emphasized the need for a well defined study to investigate the solid-state properties of selected pharmaceutical solids, the thermodynamic stability of various polymorphic ... -
WHO external quality assurance assessment scheme phase 9
Brits, Marius; Kopp, Sabine (WHO, 2020)The participation of Pharmaceutical Quality Control Laboratories (PQCLs) in appropriate proficiency testing schemes is an internationally recognised requirement1&2 as this enables the PQCL to demonstrate, monitor and ...