Browsing by Subject "Competitive"

Now showing items 1-10 of 14

    • 3-Coumaranone derivatives as inhibitors of monoamine oxidase 

      Van Dyk, Adriaan S.; Petzer, Jacobus P.; Petzer, Anél; Legoabe, Lesetja J. (Dove Press, 2015)
      The present study examines the monoamine oxidase (MAO) inhibitory properties of a series of 20 3-coumaranone [benzofuran-3(2H)-one] derivatives. The 3-coumaranone derivatives are structurally related to series of α-tetralone ...

    • Developing a competitive strategy for green buildings in South Africa 

      Grobler, Barend Gideon (North-West University (South Africa) , Potchefstroom Campus, 2016)
      Sustainable and environmental responsible initiatives play an important role in preserving and developing a country. Since awareness on sustainability is gaining traction within the market, an increasing amount of ...

    • Evaluation of natural and synthetic 1,4-naphthoquinones as inhibitors of monoamine oxidase 

      Mostert, Samantha; Petzer, Anél; Petzer, Jacobus P. (Wiley, 2016)
      Previous reports have documented that 1,4-naphtho- quinones act as inhibitors of the monoamine oxidase (MAO) enzymes. In particular, fractionation of the extracts of cured tobacco leafs has led to the charac- terization ...

    • Identification of monoamine oxidase inhibitors using a molecular modelling approach 

      Pienaar, Anke (2014)
      Monoamine oxidase (MAO) is an enzyme located on the outer mitochondrial membrane and is considered to be a target for the treatment of diseases such as Parkinson’s disease and depression. MAO may be classified into two ...

    • Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives 

      Okaecwe, Thokozile; Swanepoel, Abraham J.; Petzer, Anél; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2012)
      A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ...

    • The inhibition of monoamine oxidase by esomeprazole 

      Petzer, A.; Pienaar, A.; Petzer, J.P. (Thieme, 2013)
      Virtual screening of a library of drugs has suggested that esomeprazole, the S-enantiomer of omeprazole, may possess binding affinities for the active sites of the monoamine oxidase (MAO) A and B enzymes. Based on this ...

    • Inhibition of monoamine oxidase by selected phenylalkylcaffeine analogues 

      Petzer, Anél; Grobler, Paul; Bergh, Jacobus J.; Petzer, Jacobus P. (Wiley, 2014)
      Objectives Caffeine represents a useful scaffold for the design of monoamine oxidase (MAO) type B inhibitors. Specifically, substitution on the C8 position yields structures which are high-potency MAO-B inhibitors. To ...

    • An integrated energy management strategy for the deep-level gold mining industry 

      Bredenkamp, Johannes Izak Gabriël (North-West University (South Africa) , Potchefstroom Campus, 2016)
      In recent years, the South African deep-level gold mining industry experienced a rapid decline in gold production figures. Numerous challenges – such as lower ore-grade mining, low commodity prices and higher-than-inflation ...

    • The interactions of caffeine with monoamine oxidase 

      Petzer, Anél; Pienaar, Anke; Petzer, Jacobus P. (Elsevier, 2013)
      Aims: Caffeine has been used as a scaffold for the design of inhibitors of monoamine oxidase (MAO) A and B. Substitution at the C8 position with a variety of moieties yields structures with high MAO inhibition ...

    • Monoamine oxidase inhibitory activities of heterocyclic chalcones 

      Minders, Corné; Petzer, Jacobus P.; Petzer, Anél; Lourens, Anna C.U. (Elsevier, 2015)
      Studies have shown that natural and synthetic chalcones (1,3-diphenyl-2-propen-1-ones) possess monoamine oxidase (MAO) inhibition activities. Of particular importance to the present study is a report that a series of ...