Selective antiretroviral! (ARV) drugs are primarily metabolized by cytochrome P450 (CYP) enzymes, characteristically predisposed to variation, and are therefore primarily responsible for ARV pharmacokinetic variability and ...
Cyclosporine forms the cornerstone of therapy to prevent rejection after organ transplantation.
However, the clinical use of the drug is compromised by a narrow therapeutic window and a
wide inter- and intra-individual ...