Browsing by Author "Du Plessis, J."
Now showing items 1-20 of 75
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Characterisation, toxicology and clinical effects of crocodile oil in skin products
Venter, Telanie (North-West University, 2012)Natural oils are regularly used in cosmetics and as treatment for numeral skin conditions (Nielsen, 2006:575). The natural products industry is a multibillion dollar industry and has grown tremendously over the past few ... -
A comparability adjustment transfer pricing model
Loots, Jozua Johannes (North-West University, 2006)The birth of democracy in South Africa on 27 April 1994 brought about irrevocable change. Markets opened up, economic activity and trade accelerated resulting in the South African economy being catapulted into the global ... -
A comparative study between two lamellar gel phase systems and Emzaloids as delivery vehicles for the transdermal delivery of 5-fluorouracil and idoxuridine
Kilian, Dewald (North-West University, 2004)The distinctive architecture of the stratum corneum with its unique nature of an interstitial lipoidal environment plays the major role in regulating the barrier function of the skin. The major problem with the transdermal ... -
Comparative study of the topical delivery of selected female hormones
Bosch, Albertha Deacon (North-West University (South-Africa), 2020)Intrinsic skin ageing is predominantly caused by a decrease in female hormones as menopause approaches. It is suggested that topical application of female hormones may treat these ageing symptoms. Unfortunately, the ... -
Development and validation of the simultaneous determination of artemisone, clofazimine and decoquinate with HPLC
Du Preez, J.L.; Aucamp, M.E.; Burger, C.; Gerber, M.; Viljoen, J.M.; Van Zyl, L.; Du Plessis, J. (Avoxa, 2018)The aim of this study was to develop and validate a novel HPLC method for the simultaneous analysis of artemisone, clofazimine and decoquinate. Detection was obtained at two wavelengths; 284 nm (clofazimine) and 210 nm ... -
Development of a software-based monitoring and information system for industrial telemetry applications
Prinsloo, J.; Mathews, M.; Du Plessis, J.; Vosloo, J. (Stellenbosch Univ, 2019)Industry stands to benefit from adopting Internet of Things (IoT) practices. However, reliability and quality of service are of the utmost importance. Challenges such as intermittent connectivity in wide-area wireless ... -
Development of a topical self-emulsifying drug delivery system for optimised delivery
Van Staden, Danielleé (North-West University (South-Africa), 2020)In order to achieve successful receptor binding affinity at complex pharmacological targets the majority of drugs are of a lipophilic nature. However, optimisation of drug delivery systems for lipophilic drugs presents ... -
The effect of emulsifiers and penetration enhancers in emulsions on dermal and transdermal delivery
Otto, Anja (North-West University, 2008)Emulsions are widely used as the delivery vehicles of active ingredients. The aim of this project was the investigation of the effect of the emulsifier system on dermal and transdermal delivery. Four different actives with ... -
Effect of emulsifiers and their liquid crystalline structures in emulsions on dermal and transdermal delivery of hydroquinone, salicylic acid and octadecenedioic acid
Otto, A.; Hadgraft, J.; Du Plessis, J.; Wiechers, J.W.; Kelly, C.L. (Karger, 2010)This study investigated the effect of emulsifiers and their liquid crystalline structures on the dermal and transdermal delivery of hydroquinone (HQ), salicylic acid (SA) and octadecenedioic acid (DIOIC). Emulsions containing ... -
Effect of penetration modifiers on the dermal and transdermal delivery of drugs and cosmetic active ingredients
Otto, A.; Hadgraft, J.; Du Plessis, J.; Wiechers, J.W.; Kelly, C.L. (Karger, 2008)In this study the effect of 2 penetration modifiers, dimethyl isosorbide (DMI) and diethylene glycol monoethyl ether (DGME) on the skin delivery of hydroquinone (HQ), salicylic acid (SA) and octadecenedioic acid (DIOIC) ... -
The effect of selected natural oils on the permeation of flurbiprofen through human skin
Cowley, Amé (North-West University, 2012)In pharmaceutical sciences, topical delivery is a transport process of an active pharmaceutical ingredient (API) from a formulated dosage form to the target site of action. For most topical delivery systems, the skin ... -
The evaluation and quantification of respirable coal and silica dust concentrations: a task-based approach
Grové, T.; Franken, A.; Du Plessis, J.; Van Dyk, T. (Taylor & Francis, 2014)Silicosis and coal worker's pneumoconiosis are serious occupational respiratory diseases associated with the coal mining industry and the inhalation of respirable dusts containing crystalline silica. The purpose of this ... -
Evaluation of the medication delivery process at LIFE healthcare
Poovan, Indren Rama (North-West University, 2007)The medication administration process in Life Healthcare is a complex, multidisciplinary process with the potential for error occurring at various stages of the process. The complexity of the process makes it impossible ... -
Exploratory data analysis of the dependencies between skin permeability, molecular weight and log P
Kilian, D.; Lemmer, H.J.R.; Gerber, M.; Du Preez, J.L.; Du Plessis, J. (Govi-Verlag, 2016)Molecular weight and log P remain the most frequently used physicochemical properties in models that predict skin permeability. However, several reports over the past two decades have suggested that predictions made by ... -
Formulation and evaluation of different transdermal delivery systems with flurbiprofen as marker
Van Zyl, Lindi (North-West University, 2012)The aim of this study was to investigate the effect of different penetration enhancers containing essential fatty acids (EFAs) on the transdermal delivery of flurbiprofen. Flurbiprofen was used as a marker / model compound. ... -
Formulation and topical delivery of lidocaine and prilocaine with the use of Pheroid™ technology
Nell, Dirkie Cornelia (North-West University, 2012)Local anaesthetics are used regularly in the medical world for a variety of different procedures. Topical anaesthetics are used largely in minor skin breaking procedures, laceration repair and minor surgical procedures ... -
Formulation and topical delivery of liposomes and proliposomes containing clofazimine
Janse van Rensburg, Ewald (North-West University (South Africa) , Potchefstroom Campus, 2016)The continual market increase in the transdermal and topical delivery of drugs makes cutaneous drug delivery exploration all the more attractive for scientists (Larraῆeta et al., 2016:62). The key in the delivery of drugs ... -
Formulation and transdermal delivery of aciclovir and ketoconazole for HIV/AIDS patients
Jacobs, G.A.; Gerber, M.; Malan, M.M.; Du Preez, J.; Du Plessis, J. (Wiley, 2010)Due to their compromised immune systems, HIV/ AIDS- infected individuals are more susceptible to skin infections. Since fungal and viral cutaneous manifestations are frequently encountered in combination in HIV/AIDS patients, ... -
Formulation effects of topical emulsions on transdermal and dermal delivery
Otto, A.; Du Plessis, J.; Wiechers, J.W. (Wiley, 2009)It has been recognized that the vehicle in which a permeant is applied to the skin has a distinctive effect on the dermal and transdermal delivery of active ingredients. The cutaneous and percutaneous absorptions can be ... -
Formulation of 5–Fluorouracil for transdermal delivery
Vermaas, Monique (North-West University, 2010)Non–melanoma skin cancer (NMSC) is the most common human malignancy and it is estimated that over 1.3 million cases are diagnosed each year in the United States (Neville et al., 2007:462). There are three main types of ...