Browsing by Author "Du Plessis, Jeanetta"
Now showing items 1-20 of 41
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Bioactive albumin-based carriers for tumour chemotherapy
Shahzad, Yasser; Gerber, Minja; Du Plessis, Jeanetta; Khan, Ikram U.; Hussain, Talib (Bentham Science, 2014)Proteins are posed as the natural counterpart of the synthetic polymers for the development of drug delivery systems and few of them, have been regarded safe for drug delivery purposes by the United States Food and Drug ... -
Breaching the skin barrier through temperature modulations
Shahzad, Yasser; Louw, Ruaan; Gerber, Minja; Du Plessis, Jeanetta (Elsevier, 2015)The impermeability of the stratum corneum often hinders the transport of molecules across the skin. Temperature modulations in the skin and the application of local heat both have the potential of circumventing this problem ... -
Development of a self-emulsifying drug delivery system for optimized topical delivery of clofazimine
Van Staden, Daniélle; Du Plessis, Jeanetta; Viljoen, Joe (MDPI, 2020)A quality-by-design and characterization approach was followed to ensure development of self-emulsifying drug delivery systems (SEDDSs) destined for topical delivery of the highly lipophilic clofazimine. Solubility and ... -
Development of topical/transdermal self-emulsifying drug delivery systems, not as simple as expected
Van Staden, Daniélle; Du Plessis, Jeanetta; Viljoen, Joe (MDPI, 2020)Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs. However, the revolutionary drug delivery ... -
The effects of emulsifiers and emulsion formulation types on dermal and transdermal drug delivery
Otto, Anja; Du Plessis, Jeanetta (Springer, 2015)Emulsions are widely used in the cosmetic and pharmaceutical fields for the topical administration of hydrophilic and lipophilic active ingredients. There exist different types of emulsions, e.g. water-in-oil, oil-in-water, ... -
Essential fatty acids as transdermal penetration enhancers
Van Zyl, Lindi; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta; Viljoen, Joe (Elsevier, 2016)The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F and Pheroid™ ... -
Formulation of natural oil nano-emulsions for the topical delivery of clofazimine, artemisone and decoquinate
Burger, Cornel; Aucamp, Marique; Du Preez, Jan; Haynes, Richard K.; Du Plessis, Jeanetta; Gerber, Minja (Springer, 2018)Purpose The aim of this study was to formulate nano-emulsions comprising natural oils and the active pharmaceutical ingredients (APIs) clofazimine (CLF), artemisone (ATM) and decoquinate (DQ) in order to determine ... -
In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells
Dwivedi, Anupma; Mazumder, Anisha; Du Plessis, Lissinda; Du Preez, Jan L.; Haynes, Richard K.; Du Plessis, Jeanetta (Elsevier, 2015)Artemisone is a 10-amino-artemisinin derivative that is markedly superior in vitro and in vivo to current artemisinins against malaria and also possesses antitumor activity. In seeking to capitalise on the last property, ... -
In vitro permeation of metals through human skin: a review and recommendations
Franken, Anja; Eloff, Frederik C.; Du Plessis, Jeanetta; Du Plessis, Johannes L. (American Chemical Society, 2015)During the last few decades, the interest in skin permeation of, specifically, metals has increased with the in vitro method utilizing diffusion cells as the prominent method of investigating permeability. This review ... -
In vitro skin permeation of artemisone and its nano-vesicular formulations
Dwivedi, Anupma; Mazumder, Anisha; Fox, Lizelle T.; Brümmer, Alicia; Gerber, Minja; Du Preez, Jan L.; Haynes, Richard K.; Du Plessis, Jeanetta (Elsevier, 2016)The artemisinin derivative artemisone has antitumor activity. In particular when encapsulated in solid lipid nanoparticles (SLNs) and niosomes, it is active against human melanoma A-375 cells, although such formulations ... -
In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species
Fox, Lizelle T.; Mazumder, Anisha; Dwivedi, Anupma; Gerber, Minja; Du Plessis, Jeanetta; Hamman, Josias H. (Elsevier, 2017)Ethnopharmacological relevance Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ... -
In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex
Mazumder, Anisha; Dwivedi, Anupma; Du Preez, Jan L.; Du Plessis, Jeanetta (Elsevier, 2016)Sinigrin is a class of glucosinolates found naturally in plants of the Brassicaceae family. Lately, studies have shown that sinigrin possesses anticancer, antibacterial and anti-inflammatory activities. Since its efficacy ... -
In vivo skin hydration and anti-erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications
Fox, Lizelle T.; Du Plessis, Jeanetta; Gerber, Minja; Van Zyl, Sterna; Boneschans, Banie; Hamman, Josias H. (Medknow, 2014)To investigate the skin hydrating and anti-erythema activity of gel materials from Aloe marlothii A. Berger and A. ferox Mill. in comparison to that of Aloe barbadensis Miller (Aloe vera) in healthy human volunteers. ... -
A novel HPLC method developed and validated for the detection and quantification of atorvastatin, fluvastatin, pitavastatin and pravastatin during transdermal delivery studies
Maree, Sumari; Du Preez, Jan L.; Du Plessis, Lissinda H.; Du Plessis, Jeanetta; Gerber, Minja (Govi-Verlag, 2020)An HPLC method was developed and validated to quantify and identify several statins (atorvastatin, fluvastatin, pitavastatin and pravastatin) that were used during transdermal drug delivery. The method proved to be most ... -
Optimised transdermal delivery of pravastatin
Burger, Cornel; Gerber, Minja; Du Preez, Jan L.; Du Plessis, Jeanetta (Elsevier, 2015)Wiechers’ programme “Formulating for Efficacy” initiated a new strategy to optimise the oil phase of topical formulations in order to achieve optimal transdermal drug delivery. This new approach uses the “Delivery Gap ... -
Penetration enhancing effects of selected natural oils utilized in topical dosage forms
Viljoen, Joe M.; Cowley, Amé; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta (Taylor & Francis, 2015)Context: Various natural products, including oils, have been utilized as penetration enhancers due to their “safety profiles”. These oils contain fatty acids promoting skin permeability through lipid fluidization within ... -
Pharmaceutical applications of PheroidTM technology
Grobler, Anne Frederica (North-West University, 2009)For a drug to have a therapeutic effect, it has to reach its site of action in sufficient quantities. The Pheroid drug delivery system enhances the absorption of drugs in various pharmacological categories and is the focus ... -
Physical stability and clinical efficacy of Crocodylus niloticus oil lotion
Venter, Telanie; Fox, Lizelle Trifena; Gerber, Minja; Du Preez, Jan L.; Van Zyl, Sterna; Boneschans, Banie; Du Plessis, Jeanetta (Elsevier, 2016)The stability and the anti-ageing, skin hydrating and anti-erythema effects of a commercialized Crocodylus niloticus oil lotion was determined. The lotion was stored at controlled conditions over six months during which ... -
Quantitative determination of octadecenedioic acid in human skin and transdermal perfusates by gas chromatography-mass spectrometry.
Judefeind, Anja; Jansen van Rensburg, Peet; Du Plessis, Jeanetta; Langelaar, Stephan; Wiechers, Johann W. (Oxford Univ Press, 2008)A gas chromatographic (GC) method with mass spectrometric (MS) detection is developed and validated for the accurate and precise determination of octadecenedioic acid (C18:1 DIOIC) in human skin samples and transdermal ... -
Review of natural compounds for potential skin cancer treatment
Chinembiri, Tawona N.; Du Plessis, Lissinda H.; Gerber, Minja; Hamman, Josias H.; Du Plessis, Jeanetta (MDPI, 2014)Most anti-cancer drugs are derived from natural resources such as marine, microbial and botanical sources. Cutaneous malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. Various ...