Browsing by Author "Du Plessis, L.H."
Now showing items 1-20 of 22
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Development and evaluation of a self-emulsifying drug delivery system for artemether and lumefantrine
Cilliers, Lauren (North-West University (South-Africa), 2019)Malaria is a grave concern globally, however, in sub-Saharan Africa it remains an even more severe problem due to the fact that more than 90% of all malaria cases caused by Plasmodium falciparum reside in this region. The ... -
Development and evaluation of an oral fixed–dose triple combination dosage form for artesunate, dapsone and proguanil
Van der Merwe, Adriana Johanna (North-West University, 2011)Malaria is a life–threatening disease caused by Plasmodium spp and causes over one million deaths annually. The complex life cycle of the malaria parasite offers several points of attack for the antimalarial drugs. The ... -
Development of lipid matrix tablets containing a double-fixed dose combination of artemether and lumefantrine
Wilkins, Christi Adrienne (North-West University (South-Africa), 2019)Malaria remains one of the most serious vector-borne and prominent life-threatening diseases in sub-Saharan Africa. Africa has the heaviest malarial disease burden in the world, accounting for 91% of the estimated 445 000 ... -
DNA damage and repair detected by the comet assay in lymphocytes of African petrol attendants: a pilot study
Keretetse, G.S.; Laubscher, P.J.; Du Plessis, J.L.; Pretorius, P.J.; Van der Westhuizen, F.H.; Van Deventer, E.; Van Dyk, E.; Eloff, F.C.; Van Aarde, M.N.; Du Plessis, L.H. (Oxford Univ Press, 2008)Petrol attendants are exposed to petrol volatile organic compounds (VOCs) which may have genotoxic and carcinogenic effects. The single-cell gel electrophoresis assay (comet assay) is a method highly sensitive to DNA damage ... -
Efficacy enhancement of the antimalarial drugs, mefloquine and artesunate, with PheroidTM technology
Van Huyssteen, Este (North-West University, 2010)Malaria is currently one of the most imperative parasitic diseases in developing countries. Artesunate has a short half-life, low aqueous solubility and resultant poor and erratic absorption upon oral administration, which ... -
Enhancement of nasal and intestinal calcitonin delivery by the novel PheroidTM fatty acid based delivery system, and by N-trimethyl chitosan chloride
Du Plessis, L.H.; Lubbe, J.; Strauss, T.; Kotzé, A.F. (Elsevier, 2010)Therapeutic peptides are highly potent and specific in their functions, but difficulties in their administration require parallel development of viable delivery systems to improve their bioavailability. In this study the ... -
Evaluation and validation of methods to determine parasitemia in malaria cell cultures
Slabbert, Chrizaan (North-West University, 2008)The success in the treatment of malaria is dependent on the prompt and accurate diagnosis of malaria and effectiveness of the drug regime used. The emerging of resistance to most antimalarial drug makes the treatment of ... -
Evaluation of the physical properties and stability of two lipid drug delivery systems containing mefloquine
Slabbert, C.; Kotzé, A.F.; Du Plessis, L.H. (Elsevier, 2011)Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy ... -
Formulation, characterisation and in vivo efficacy of dapsone and proguanil in trimethylated chitosan microparticles
Van Heerden, Jacobus (2014)Malaria is an infectious disease caused by various forms of the Plasmodium parasite. It is responsible for thousands of deaths yearly with 90 % of those deaths being in sub-Saharan Africa, thus making it a disease of global ... -
Formulation, characterization and cellular toxicity of lipid based drug delivery systems for mefloquin
Helena (nee Slabbert), Chrizaan (North-West University, 2011)Malaria affects millions of people annually especially in third world countries. Increase in resistance and limited research being conducted adds to the global burden of malaria. Mefloquine, known for unwanted adverse ... -
Hemocompatibility of N–trimethyl chitosan chloride nanoparticles
Du Toit, Lizl (2014)Research on nanoparticles for pharmaceutical applications has become increasingly popular in recent years. N-trimethyl chitosan chloride (TMC) is a cationic polymer that can enhance absorption across mucosal surfaces. It ... -
An in vitro evaluation of the antibacterial and anticancer properties of the antimicrobial peptide nisin Z
Lewies, Angélique (North-West University (South Africa), Potchefstroom Campus, 2018)The rise in antibiotic resistance and the lack of the development of new antibiotics poses a considerable threat to human health. This is especially of concern in individuals who are immune-compromised (due to immunosuppressive ... -
In vitro evaluation of the cytotoxic, antibacterial and antioxidant properties of selected chitosan derivatives and melittin
Jacobs, Garmi (North-West University (South Africa) , Potchefstroom Campus, 2015)New excipients to improve the oral absorption of drugs are developing significantly. Polymers are used to enhance drug absorption through the gastrointestinal tract. Chitosan is a biocompatible polymer that is capable of ... -
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid
Booysen, L.L.I.J.; Kotzé, A.F.; Du Plessis, L.H.; Kalombo, L.; Brooks, E. (Elsevier, 2013)Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small ... -
Novel artemisinin derivatives with PheroidTM technology for malaria treatment
Steyn, Johan Dewald (North-West University, 2009)Artemisinins are known for their low aqueous solubility and resultant poor and erratic absorption upon oral administration. The poor solubility and erratic absorption usually translate, to low bibavailability. Enzymatic ... -
Pheroid technology for the topical delivery of depigmenting agents transforming growth factor–ß1 and tumor necrosis factor–a
Campbell, Berenice (North-West University, 2010)Pigmentation disorders occur in multiple conditions (Hakozaki et al., 2006:105). Although many modalities of treatments are available, none are completely satisfactory (Briganti et al., 2003:101). Two cytokines normally ... -
Pheroid technology for the topical delivery of insulin growth factor 1 (IGF-1), keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF)
Van Niekerk, Lize (North-West University, 2009)The biotechnological era is here and many peptides and proteins are being used as part of drug therapy. They are, however, not very stable and do not have the physicochemical properties that allow for oral or topical ... -
Preparation, stability and in vitro evaluation of liposomes containing chloroquine
Nieuwoudt, Stephnie (North-West University, 2010)Malaria is currently a huge treat worldwide, as far as infections are concerned, and is responsible for thousands of deaths per annum. The dilemma associated with the development of anti–malarial drug resistance over the ... -
The protective effect of plasma antioxidants during ozone autohemotherapy
Du Plessis, L.H.; Van der Westhuizen, F.H.; Kotzé, H.F. (Academic Journals, 2008)Ozone (O3) therapy forms part of a group of complementary and alternative medical therapies and is gaining more and more interest worldwide. There is, however, some concern regarding O3-toxicity and uncertainty about the ... -
Southern African scorpion toxins: an overview
Du Plessis, L.H.; Elgar, D.; Du Plessis, J.L. (Elsevier, 2008)In southern Africa there are 130 species of scorpions and only a few species’ venom have been investigated to date. This review gives an overview of the research done on the venom of southern African scorpions and the ...