Browsing by Author "Du Preez, Jan"
Now showing items 1-6 of 6
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The antioxidant properties of the methanol extract of Cotyledon orbiculata L. var orbiculata (Haw.) DC. Leaves
Roux, Wessel Cornelius (North-West University, [2012])South Africa is a country of great diversity. Different climate zones and a host of different habitats make South Africa the perfect platform for rich floral diversity. This floral diversity lends itself to the study of ... -
Essential fatty acids as transdermal penetration enhancers
Van Zyl, Lindi; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta; Viljoen, Joe (Elsevier, 2016)The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F and Pheroid™ ... -
Formulation of natural oil nano-emulsions for the topical delivery of clofazimine, artemisone and decoquinate
Burger, Cornel; Aucamp, Marique; Du Preez, Jan; Haynes, Richard K.; Du Plessis, Jeanetta; Gerber, Minja (Springer, 2018)Purpose The aim of this study was to formulate nano-emulsions comprising natural oils and the active pharmaceutical ingredients (APIs) clofazimine (CLF), artemisone (ATM) and decoquinate (DQ) in order to determine ... -
Penetration enhancing effects of selected natural oils utilized in topical dosage forms
Viljoen, Joe M.; Cowley, Amé; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta (Taylor & Francis, 2015)Context: Various natural products, including oils, have been utilized as penetration enhancers due to their “safety profiles”. These oils contain fatty acids promoting skin permeability through lipid fluidization within ... -
Topical delivery of 5-fluorouracil from Pheroid™ formulations and the in vitro efficacy against human melanoma
Chinembiri, Tawona N.; Gerber, Minja; Du Plessis, Lissinda; Du Preez, Jan; Du Plessis, Jeanetta (Springer, 2015)Drug delivery vehicles can influence the topical delivery and the efficacy of an active pharmaceutical ingredient (API). In this study the influence of Pheroid™ technology, which is a unique colloidal drug delivery system, ... -
Transport of aspalathin, a rooibos tea flavonoid, across the skin and intestinal epithelium
Huang, Miao; Du Plessis, Jeanetta; Du Preez, Jan; Hamman, Josias; Viljoen, Alvaro (Wiley, 2008)Since Rooibos tea contains high levels of flavonoid antioxidants with potential health benefits when taken orally or applied topically, the quantity of the antioxidants crossing the physiological barriers is of scientific, ...