Browsing by Subject "Escitalopram"
Now showing items 1-10 of 15
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Chronic effects of pre-adolescent pharmacological and non-pharmacological interventions on depressive-like behaviour in rats
(North-West University, 2018)Similar to adults, major depressive disorder (MDD) also affects children and adolescents, with comparable treatment outcomes. However, only two antidepressants, namely the serotonin reuptake inhibitors fluoxetine and ... -
Cognitive flexibility in the deer mouse and its response to escitalopram and levetiracetam
(North-West University (South-Africa), 2022)Obsessive-compulsive disorder (OCD)1 causes functional impairment which severely and negatively impacts the lives of affected individuals. As its name suggests, OCD is characterised by both obsessions and compulsions. The ... -
Cognitive flexibility in the deer mouse model of obsessive-compulsive disorder and its response to serotonin and adenosine modulation
(North-West University (South-Africa), 2021)Obsessive-compulsive disorder (OCD)1 is a phenotypically heterogeneous psychiatric disorder characterised by repetitive and ritualised behaviours (compulsions), that are purportedly enacted to attenuate the level of distress ... -
Immediate and long-term antidepressive-like effects of pre-pubertal escitalopram and omega-3 supplementation combination in young adult stress-sensitive rats
(Elsevier, 2018)Major depressive disorder (MDD) affects a significant number of children and adolescents, yet treatment options for this population remain very limited. Escitalopram (ESC) is one of only two antidepressants approved as ... -
Large nest building and high marble-burying: two compulsive-like phenotypes expressed by deer mice (Peromyscus maniculatus bairdii) and their unique response to serotoninergic and dopamine modulating intervention
(Elsevier, 2020)This study aimed to further dissect the deer mouse (Peromyscus maniculatus bairdii) model of compulsive-like behavior with respect to two persistent-like behavioral phenotypes viz. large nest building (LNB) and high ... -
A metagenomic microbiome investigation in the deer mouse : a translational approach to obsessive-compulsive disorder
(North-West University (South-Africa), 2019)Obsessive-compulsive disorder (OCD)1 is characterized by persistent, intrusive and often anxiety-provoking thoughts, i.e. obsessions and/or ritualistic behaviors (compulsions) that are expressed in an attempt to reduce the ... -
Naturalistic operant responses in deer mice (Peromyscus maniculatus bairdii) and its response to outcome manipulation and serotonergic intervention
(Wolters Kluwer, 2020)Investigating the motivational triggers underlying naturalistic compulsive-like behavior is generally regarded as challenging. To this extent, the current study aimed to establish a proof-of-concept for future investigation ... -
Nest building and marble burying: Dopaminergic phenotyping of the deer mouse model of obsessive-compulsive disorder (OCD)
(North-West University (South-Africa), 2020)Obsessive-compulsive disorder (OCD1) is a chronic, debilitating psychiatric condition that affects 3% of the global population and is characterized by obsessions, and compulsions. 40 – 60% of patients remain treatment-resistant ... -
Of mice and marbles: novel perspectives on burying behavior as a screening test for psychiatric illness
(Springer, 2016)Burying forms part of the normal behavioral routine of rodents, although its expression is species-specific. However, it has been suggested that aberrant burying behavior, of which marble-burying (MB) is an example, may ... -
Persistent behavioural phenotypes in the deer mouse and its response to serotonergic and dopaminergic intervention
(North-West University (South-Africa), 2019)Obsessive compulsive disorder (OCD)1 is a debilitating psychiatric disorder that presents with intrusive thoughts (obsessions) and repetitive ritualistic behaviour (compulsions) as main symptoms. Selective reuptake inhibitors ...