Now showing items 1-20 of 27

    • Bioactive albumin-based carriers for tumour chemotherapy 

      Shahzad, Yasser; Gerber, Minja; Du Plessis, Jeanetta; Khan, Ikram U.; Hussain, Talib (Bentham Science Publishers, 2014)
      Proteins are posed as the natural counterpart of the synthetic polymers for the development of drug delivery systems and few of them, have been regarded safe for drug delivery purposes by the United States Food and Drug ...
    • Bioactive albumin-based carriers for tumour chemotherapy 

      Shahzad, Yasser; Gerber, Minja; Du Plessis, Jeanetta; Khan, Ikram Ullah; Hussain, Talib; Alamgeer; Serra, Christophe A. (Bentham Science Publishers, 2014)
      Proteins are posed as the natural counterpart of the synthetic polymers for the development of drug delivery systems and few of them, have been regarded safe for drug delivery purposes by the United States Food and Drug ...
    • Breaching the skin barrier through temperature modulations 

      Shahzad, Yasser; Louw, Ruaan; Gerber, Minja; Du Plessis, Jeanetta (Elsevier, 2015)
      The impermeability of the stratum corneum often hinders the transport of molecules across the skin. Temperature modulations in the skin and the application of local heat both have the potential of circumventing this problem ...
    • Essential fatty acids as transdermal penetration enhancers 

      Van Zyl, Lindi; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta; Viljoen, Joe (Wiley, 2015)
      The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F and Pheroid™ ...
    • In vitro skin permeation of artemisone and its nano-vesicular formulations 

      Dwivedi, Anupma; Mazumder, Anisha; Fox, Lizelle T.; Brümmer, Alicia; Gerber, Minja; Du Preez, Jan L.; Haynes, Richard K.; Du Plessis, Jeanetta (Elsevier, 2016)
      The artemisinin derivative artemisone has antitumor activity. In particular when encapsulated in solid lipid nanoparticles (SLNs) and niosomes, it is active against human melanoma A-375 cells, although such formulations ...
    • In vivo skin hydration and anti-erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications 

      Fox, Lizelle T; Du Plessis, Jeanetta; Gerber, Minja; Van Zyl, Sterna; Boneschans, Banie; Hamman, Josias H (Medknow Publications, 2014)
      Background: Although Aloe vera extracts have exhibited various effects on the skin, less is known about the biological activities of other aloe species on the skin. Objective: To investigate the skin hydrating and anti-erythema ...
    • Optimised transdermal delivery of pravastatin 

      Burger, Cornel; Gerber, Minja; Du Preez, Jan L.; Du Plessis, Jeanetta (Elsevier, 2015)
      Wiechers’ programme “Formulating for Efficacy” initiated a new strategy to optimise the oil phase of topical formulations in order to achieve optimal transdermal drug delivery. This new approach uses the “Delivery Gap ...
    • Penetration enhancing effects of selected natural oils utilized in topical dosage forms 

      Viljoen, Joe M.; Cowley, Amé; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta (Taylor & Francis, 2015)
      Context: Various natural products, including oils, have been utilized as penetration enhancers due to their “safety profiles”. These oils contain fatty acids promoting skin permeability through lipid fluidization within ...
    • Physical stability and clinical efficacy of Crocodylus niloticus oil lotion 

      Venter, Telanie; Fox, Lizelle T.; Gerber, Minja; Du Preez, Jan L.; Van Zyl, Sterna; Boneschans, Banie; Du Plessis, Jeanetta (Sociedade Brasileira de Farmacognosia, 2016)
      The stability and the anti-ageing, skin hydrating and anti-erythema effects of a commercialized Crocodylus niloticus oil lotion was determined. The lotion was stored at controlled conditions over six months during which ...
    • Review of natural compounds for potential skin cancer treatment 

      Chinembiri, Tawona N.; Du Plessis, Lissinda H.; Gerber, Minja; Hamman, Josias H.; Du Plessis, Jeanetta (MDPI, 2014)
      Most anti-cancer drugs are derived from natural resources such as marine, microbial and botanical sources. Cutaneous malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. Various ...
    • Review of natural compounds for potential skin cancer treatment 

      Chinembiri, Tawona N; Du Plessis, Lissinda H; Gerber, Minja; Hamman, Josias H; Du Plessis, Jeanetta (MDPI, 2014)
      Most anti-cancer drugs are derived from natural resources such as marine, microbial and botanical sources. Cutaneous malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. Various ...
    • Skin permeation enhancement effects of the gel and whole 1 leaf materials of A. vera, A. marlothii and A. ferox 

      Fox, Lizelle T.; Gerber, Minja; Du Preez, Jan L.; Du Plessis, Jeanetta; Hamman, Josias H. (Royal Pharmaceutical Society of Great Britain, 2015)
      Objectives: The aim of this study was to investigate the in vitro permeation enhancement effects of the gel and whole leaf materials of Aloe vera, Aloe marlothii and Aloe ferox using ketoprofen as a marker compound. Methods: ...
    • Stability, clinical efficacy and antioxidant properties of honeybush extracts in semi-solid formulations. 

      Gerber, Gezina S.F.W.; Fox, Lizelle T.; Gerber, Minja; Du Preez, Jan L.; Van Zyl, Sterna; Boneschans, Banie; Du Plessis, Jeanetta (Medknow Publications, 2015)
      Background: Honeybush extracts (Cyclopia spp.) can be incorporated into skin care products to treat conditions such as skin dryness and can function as an anti-oxidant. Objective: To formulate Honeybush formulations and ...
    • Synthesis and transdermal penetration of selected lamivudine derivatives / Minja Gerber 

      Gerber, Minja (North-West University, 2007)
      The skin is the most extensive and readily accessible organ in the body. The outermost layer of the skin, the stratum corneum, functions as a barrier, limiting the transport of molecules into and across the skin. Transdermal ...
    • Synthesis and transdermal penetration of stavudine-5'-esters 

      Breytenbach, Jaco Cornelius; Du Plessis, Jeanetta; Gerber, Minja; Holmes, Estee-marie (Bentham Science Publishers, 2010)
      The aim of this study was to investigate the effects of different ester groups in position 5 of stavudine on the transdermal penetration with and without the use of Pheroid™ as the delivery system. Six esters were prepared ...
    • Synthesis and transdermal penetration of stavudine-5'-esters. 

      Holmes, Estée-Marie; Breytenbach, Jaco C.; Gerber, Minja; Du Plessis, Jeanetta (Bentham Science Publishers, 2010)
      The aim of this study was to investigate the effects of different ester groups in position 5’ of stavudine on the transdermal penetration with and without the use of Pheroid™ as the delivery system. Six esters were prepared ...
    • Synthesis and transdermal properties of acetylsalicylic acid and selected esters 

      Gerber, Minja; Breytenbach, Jaco C; Hadgraft, Jonathan; Du Plessis, Jeanetta (Elsevier, 2006)
      The primary aim of this study was to determine the transdermal penetration of acetylsalicylic acid and some of its derivatives, to establish a correlation, if any, with selected physicochemical properties and to determine ...
    • Synthesis and transdermal properties of acetylsalicylic acid derivates / Minja Gerber 

      Gerber, Minja (North-West University, 2003)
      The skin is an amazing elastic and relatively impermeable barrier that provides protective, perceptive and communication functions to the body. The stratum corneum is widely accepted as the barrier of the skin - limiting ...
    • Topical and transdermal delivery of L-Carnitine 

      Fox, Lizelle Trifena; Gerber, Minja; Grobler, Anne Frederica; Du Preez, Jan Lourens; Du Plessis, Jeanetta (Karger, 2011)
      Background: The two types of skin aging (intrinsic and extrinsic) share important molecular features, while having distinct differences on the macromolecular level: both lead to increased production of reactive oxygen ...
    • Topical and transdermal delivery of L-carnitine 

      Fox, Lizelle T.; Gerber, Minja; Du Preez, Jan L.; Grobler, Anne; Du Plessis, Jeanetta (Karger, 2011)
      Background: The two types of skin aging (intrinsic and extrinsic) share important molecular features, while having distinct differences on the macromolecular level: both lead to increased production of reactive oxygen ...