Browsing by Subject "Glutamate"
Now showing items 1-8 of 8
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Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: effect of ketamine
(Wiley, 2017)Major depressive disorder (MDD) is associated with dysfunctional serotonergic and glutamatergic neurotransmission, and the genetic animal model of depression Flinders Sensitive Line (FSL) rats display alterations in these ... -
Investigating the role of the NO-cGMP pathway in an animal model of posttraumatic stress disorder (PTSD)
(North-West University, 2004)Posttraumatic stress disorder (PTSD) is a severe anxiety disorder characterised by hypothalamic-pituitary-adrenal (HPA)-axis abnormalities, hyperarousal, anxiety, flashbacks of trauma memories and avoidance. Increasing ... -
Is major depressive disorder a metabolic encephalopathy?
(Wiley, 2008)Metabolic encephalopathy is an acute disturbance in cellular metabolism in the brain evoked by conditions of hypoxia, hypoglycaemia, oxidative stress and/or inflammation. It usually develops acutely or subacutely and is ... -
Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models
(Elsevier, 2012)Anxiety disorders are amongst the most common and disabling of psychiatric illnesses and have severe health and socio-economic implications. Despite the availability of a number of treatment options there is still a strong ... -
A new efficient method for synaptic vesicle quantification reveals differences between medial prefrontal cortex perforated and nonperforated synapses
(Wiley, 2014)Communication between neurons is mediated by the release of neurotransmitter-containing vesicles from presynaptic terminals. Quantitative characterization of synaptic vesicles can be highly valuable for understanding ... -
Potential involvement of serotonergic signaling in ketamine's antidepressant actions: a critical review
(Elsevier, 2016)A single i.v. infusion of ketamine, classified as an N-methyl-d-aspartate (NMDA) receptor antagonist, may alleviate depressive symptoms within hours of administration in treatment resistant depressed patients, and the ... -
Regional neurochemical characterization of the flinders sensitive line rat with regard to gaba and cholinergic signalling pathways
(North-West University, 2008)Despite their acknowledged efficacy, currently available antidepressants still demonstrate undesirable side effects, shortfalls in effectiveness and a delayed onset of action. All these agents act via monoaminergic mechanisms, ... -
Tryptophan metabolism in the deer mouse and its response to serotonergic intervention
(North-West University (South-Africa), 2022)Obsessive-compulsive disorder (OCD)1 is a debilitating neuropsychiatric condition that notably infringes on an individual’s quality of life. The condition is characterised by two primary symptoms, namely obsessions (intrusive ...