Now showing items 1-7 of 7

    • Absorption of the novel artemisinin derivatives artemisone and artemiside: potential application of Pheroid™ technology 

      Grobler, Anne Frederica; Smith, Peter; Steyn, Johan Dewald; Wiesner, Lubbe; Du Plessis, Lissinda Hester; Smith, Peter J.; Chan, Wing-Chi; Haynes, Richard K.; Kotzé, Abraham Frederick (Awie (Elsevier, 2011)
      Artemisinins have low aqueous solubility that results in poor and erratic absorption upon oral administration. The poor solubility and erratic absorption usually translate to low bioavailability. Artemisinin-based monotherapy ...
    • Influence of variation in eumelanin content on absorbance spectra of liquid skin-like phantoms 

      Grobler, Anne Frederica; Smit, Jacoba; Sparrow, Raymond (Wiley-Blackwell, 2011)
      The attenuation behavior of two different types of skin-like phantoms representing the range of Fitzpatrick skin Types I–VI was investigated and compared with real human skin. Intralipid (IL) and Pheroid™ artificial lipid ...
    • Nano & micro-delivery systems : the Pheroid® story / Anne Frederica Grobler 

      Grobler, Anne Frederica (2013)
      For a drug to have a therapeutic effect, it has to reach its site of action in sufficient quantities. The Pheroid® delivery system enhances the absorption of various pharmacological compounds and biological molecules. The ...
    • Pharmaceutical applications of PheroidTM technology / Anne F. Grobler 

      Grobler, Anne Frederica (North-West University, 2009)
      For a drug to have a therapeutic effect, it has to reach its site of action in sufficient quantities. The Pheroid drug delivery system enhances the absorption of drugs in various pharmacological categories and is the focus ...
    • Rapid cell lysis and DNA capture in a lysis microreactor 

      Booth, Christine; Grobler, Anne Frederica; Levanets, Oskana; Viljoen, Hendrik; Whitney, Scott (Elsevier, 2012)
      In clinical diagnostics, the detection and identification of bacterial organisms based on the analysis of their nucleic acids require cell lysis and DNA extraction from clinical samples. A lysis microreactor (LMR) has been ...
    • Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy 

      Aminake, Makoah; Grobler, Anne Frederica; Hans, Renate; Kumar, Vipan; Mahajan, Aman; Wiesner, Lubbe (Elsevier, 2012)
      Malaria and HIV are among the most important global health problems of our time and together are responsible for approximately 3 million deaths annually. These two diseases overlap in many regions of the world including ...
    • Topical and transdermal delivery of L-Carnitine 

      Fox, Lizelle Trifena; Gerber, Minja; Grobler, Anne Frederica; Du Preez, Jan Lourens; Du Plessis, Jeanetta (Karger, 2011)
      Background: The two types of skin aging (intrinsic and extrinsic) share important molecular features, while having distinct differences on the macromolecular level: both lead to increased production of reactive oxygen ...