Browsing by Author "Grobler, Lizette"
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Assessment of the induction of dormant ring stages in Plasmodium falciparum parasites by artemisone and artemisone entrapped in Pheroid vesicles in vitro
Grobler, Lizette; Haynes, Richard K.; Grobler, Anne F.; Chavchich, Marina; Edstein, Michael D. (American Society for Microbiology, 2014)The in vitro antimalarial activities of artemisone and artemisone entrapped in Pheroid vesicles were compared, as was their ability to induce dormancy in Plasmodium falciparum. There was no increase in the activity of ... -
The effect of Pheroid® technology on the bioavailability of artemisone in primates
Grobler, Lizette (2014)Malaria is one the world’s most devastating diseases. Several classes of drugs are used to treat malaria. Artemisinin combination therapy is the first line treatment of uncomplicated malaria. The artemisinin derivative, ... -
The effect of the Pheroid delivery system on the in vitro metabolism and in vivo pharmacokinetics of artemisone
Grobler, Lizette; Grobler, Anne; Haynes, Richard; Steyn, Hendrik Stefanus; Masimirembwa, Collen; Thelingwani, Roslyn (Taylor & Francis, 2014)Objectives: The objectives were to determine the pharmacokinetics (PK) of artemisone and artemisone formulated in the Pheroid® drug delivery system in primates and to establish whether the formulation affects the in vitro ...