Browsing by Author "Harmse, Rozanne"
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Activities of 11-azaartemisinin and N-sulfonyl derivatives against asexual and transmissible malaria parasites
Harmse, Rozanne; Wong, Ho Ning; Smit, Frans J.; Haynes, Richard K.; N'Da, David D. (Wiley, 2017)Dihydroartemisinin (DHA), either used in its own right or as the active drug generated in vivo from the other artemisinins in current clinical use—artemether and artesunate—induces quiescence in ring-stage parasites of ... -
Activities of 11-azaartemisinin and N-sulfonyl derivatives against Neospora caninum and comparative cytotoxicities
Harmse, Rozanne; Wong, Ho Ning; Smit, Frans J.; N'Da, David D.; Haynes, Richard K. (Wiley, 2017)Neosporosis caused by the apicomplexan parasite Neospora caninum is an economically important disease that induces abortion in dairy and beef cattle. There are no vaccines or drugs available on the market for control or ... -
The case for development of 11-aza-artemisinins for malaria
Harmse, Rozanne; Smit, Frans; Haynes, Richard K.; N'Da, David D.; Wong, Ho Ning (Bentham Science, 2015)The current treatment regimens for uncomplicated malaria comprise an artemisinin in combination with another drug (ACT). However, the recent emergence of resistance to ACTs in South East Asia dramatically emphasizes the ... -
Discovery of 1,3-diethyl-7-methyl-8-(phenoxymethyl)-xanthine derivatives as novel adenosine A1 and A2A receptor antagonists
Harmse, Rozanne; Van der Walt, Mietha M.; Petzer, Jacobus P.; Terre'Blanche, Gisella (Elsevier, 2016)Based on a previous report that a series of 8-(phenoxymethyl)-xanthines may be promising leads for the design of A1 adenosine receptor antagonists, selected novel and known 1,3-diethyl-7-methyl-8-(phenoxymethyl)-xanthine ... -
Syntheses of 8–(phenoxymethyl)caffeine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of the adenosine A2A receptor
Harmse, Rozanne (North-West University, 2013)Background and rationale: Parkinson’s disease (PD) is a progressive, degenerative disorder of the central nervous system and is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The ...