Browsing by Author "Harvey, Brian H."
Now showing items 1-20 of 88
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Adverse neuropsychiatric events and recreational use of efavirenz and other HIV-1 antiretroviral drugs
Dalwadi, Dhwanil A.; Harvey, Brian H.; Viljoen, Michelle; Ozuna, Luis; Schetz, John A. (ASPET, 2018)Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep disturbances, nervousness, anxiety, depression, ... -
The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats
Hamlyn, Eugene; Brand, Linda; Harvey, Brian H.; Shadid, Mohammed (Wolters Kluwer, 2009)Ampakines have shown beneficial effects on cognition in selected animal models of learning. However, their ability to modify long-term spatial memory tasks has not been studied yet. This would lend credence to their possible ... -
Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression
Liebenberg, Nico; Harvey, Brian H.; Brand, Linda; Brink, Christiaan B. (Wolters Kluwer, 2010)We explored the antidepressant-like properties of two phosphodiesterase type 5 (PDE5) inhibitors in a genetic animal model of depression, namely Flinders sensitive line rats. We investigated the dose-dependency of the ... -
Appraisal of ozone as biologically active molecule and experimental tool in biomedical sciences
Mokoena, Mmalebuso L.; Brink, Christiaan B.; Harvey, Brian H.; Oliver, Douglas W. (Springer, 2011)Ozone (O3) (CAS 10028-15-6) is a major air industrial pollutant and is well known for its very strong oxidative actions which affords the molecule its useful antimicrobial and deodorizing properties, but also its potential ... -
Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties
Delport, Anzelle; Harvey, Brian H.; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2014)Aims: The phenothiazinium compound, methylene blue (MB), possesses diverse pharmacological actions and is attracting attention for the treatment of bipolar disorder and Alzheimer's disease. MB acts on both monoamine oxidase ... -
Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase
Petzer, Anél; Harvey, Brian H.; Petzer, Jacobus P.; Wegener, Gregers (Elsevier, 2012)Methylene blue (MB) has been shown to act at multiple cellular and molecular targets and as a result possesses diverse medical applications. Among these is a high potency reversible inhibition of monoamine oxidase A ... -
Blunted neuro-endocrine responses linking depressive symptoms and ECG left ventricular hypertrophy in black Africans: the SABPA study
Mashele, Nyiko; Malan, Leoné; Van Rooyen, Johannes M.; Harvey, Brian H.; Potgieter, Johan C.; Hamer, Mark (Wolters Kluwer, 2014)Objective: Chronic psychosocial stress as experienced in an urban environment plays an important role in the aetiology of depression-related cardiovascular risk. It is uncertain whether acute mental stress responses aggravate ... -
Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology
Daniels, Willie M.U.; Savitz, Jonathan (Cambridge Univ Press, 2008)While monoaminergic hypotheses of psychopathology remain popular, there has been growing interest in the role of neurotrophins in neuropsychiatric disorders. Basic laboratory work has documented the importance of neurotrophins ... -
Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: the SABPA study
Malan, Leoné; Hamer, Mark; Von Känel, Roland; Harvey, Brian H.; Steyn, Faans; Malan, Nico T. (Elsevier, 2016)Background Depression has been associated with impaired nitric oxide (NO)-mediated vasodilation and vascular dysregulation (VD). Whether depression and NO levels will disturb retinal haemodynamics is not clear. Objectives ... -
Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats
Liebenberg, Nico; Harvey, Brian H.; Brand, Linda; Brink, Christiaan B.; Wegener, Gregers (Springer, 2012)There are conflicting results from behavioural studies regarding whether the activation or inhibition of the cGMP-nitric oxide (NO) pathway induces anxiolytic-like behaviour. Sildenafil, an inhibitor of cGMP-selective ... -
Cortical brain release of glutamate by ketamine and fluoxetine : an in vivo microdialysis study in the Flinders sensitive line rat
Visser, Gert Petrus (North-West University, 2012)In vivo intracranial microdialysis is a valuable technique yielding novel and useful insight into normal or pathological neurochemical processes in the brain by means of sampling of interstitial fluid of cells in a living ... -
Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment
Korff, Schaun; Harvey, Brian H.; Stein, Dan J. (Elsevier, 2009)Motor stereotypies, described as repetitive, topographically invariant and seemingly purposeless behaviours, are common to several developmental and neuropsychiatric disorders. While drug induced stereotypy has been ... -
Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse
Güldenpfennig, Marianne; Wolmarans, De Wet; Du Preez, Jan L.; Harvey, Brian H.; Stein, Dan J. (Elsevier, 2011)The deer mouse presents with spontaneous stereotypic movements that resemble the repetitive behaviours of obsessive–compulsive disorder (OCD), and demonstrates a selective response to serotonin reuptake inhibitors. OCD has ... -
Corticolimbic changes in acetylcholine and cyclic guanosine monophosphate in the Flinders Sensitive Line rat: a genetic model of depression
Brand, Linda; Van Zyl, Jurgens; Minnaar, Estella L.; Viljoen, Francois; Du Preez, Jan L.; Harvey, Brian H. (Cambridge, 2012)Objective: Depression is suggested to involve disturbances in cholinergic as well as glutamatergic pathways, particularly the N-methyl-d-aspartate receptor-mediated release of nitric oxide (NO) and cyclic guanosine ... -
A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: mapping the way forward
De Brouwer, Geoffrey; Fick, Arina; Harvey, Brian H.; Wolmarans, De Wet (Springer, 2019)Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or measure to study anxiety- and compulsive-like behaviors or anxiolytic and anticompulsive drug action. However, the test responds ... -
Cross-species analyses of intra-species behavioral differences in mammals and fish
Demin, Konstantin A.; Harvey, Brian H.; Lakstygal, Anton M.; Volgin, Andrey D.; De Abreu, Murilo S. (Elsevier, 2020)Multiple species display robust behavioral variance among individuals due to different genetic, genomic, epigenetic, neuroplasticity and environmental factors. Behavioral individuality has been extensively studied in various ... -
Depression symptoms facilitated fibrinolytic dysregulation and future coronary artery disease risk in a black male cohort: the sympathetic activity and ambulatory blood pressure in Africans study
Malan, Leoné; Mashele, Nyiko; Malan, Nicolaas T.; Harvey, Brian H.; Potgieter, Johan C.; Van Rooyen, Johannes M. (Wolters Kluwer, 2017)Background: Hypercoagulation is associated with coronary artery disease (CAD). Whether depression symptoms dysregulate inflammatory and hemostatic markers in an African cohort is not known; therefore, we assessed the ... -
Depression, cardiometabolic function and left ventricular hypertrophy in African men and women: the SABPA study
Mashele, Nyiko; Malan, Leoné; Van Rooyen, Johannes M.; Harvey, Brian H.; Potgieter, Johan C.; Hamer, Mark (Taylor & Francis, 2013)Depressive symptoms are associated with an increased risk for developing cardiovascular diseases, driven by its link to the metabolic syndrome (MetS). This phenomenon, however, still needs to be investigated in the African ... -
Depressive symptoms and 24-hour ambulatory blood pressure in Africans: the SABPA study
Hamer, Mark; Harvey, Brian H.; Malan, Nico T.; Malan, Leoné; Frasure-Smith, Nancy (Hindawi, 2012)Disturbances in circadian rhythm might play a central role in the neurobiology of depression. We examined the association between depressive symptoms and 24-hour ambulatory BP in a sample of 405 (197 black and 208 Caucasian) ... -
Depressive symptoms and sub-clinical atherosclerosis in Africans: role of metabolic syndrome, inflammation and sympathoadrenal function
Hamer, Mark; Malan, Nicolaas T.; Harvey, Brian H.; Malan, Leoné (Elsevier, 2011)Depressive symptoms have been consistently associated with sub-clinical atherosclerosis and future risk of coronary heart disease events. However, the pathways linking depression and coronary atherosclerosis are poorly ...