Browsing by Subject "Hepatocellular carcinoma"
Now showing items 1-4 of 4
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Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation
(Taylor & Francis, 2013)Introduction: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13), is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A ... -
Impaired DNA repair and genomic stability in hereditary tyrosinemia type 1
(Elsevier, 2012)The autosomal recessive disorder, hereditary tyrosinemia type 1 (HT1), is caused by a defective fumarylacetoacetate hydrolase enzyme. Consequently intermediate metabolites such as fumarylacetoacetate, succinylacetone and ... -
The molecular basis of the genetic mosaicism in hereditary tyrosinemia (HT1)
(North-West University, 2011)Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disorder of the tyrosine degradation pathway. The defective fumarylacetoacetate hydrolase enzyme causes the accumulation of upstream metabolites such as ... -
Tyrosinemia type I as a model for studying epigenetic events in the aetiology of metabolic disease associated hepatocarcinoma
(North-West University, 2011)Occupational risk management can be a catalyst in generating superior returns for all stakeholders on a sustainable basis. A number of companies in South Africa have implemented Cardinal Rules of Safety adopted from ...