Browsing by Author "Kleynhans, Janke"

Now showing items 1-4 of 4

    • Aminopyrimidine derivatives as adenosine antagonists 

      Kleynhans, Janke (2013)
      Aims of this project - The aim of this study was to design and synthesise novel 2-aminopyrimidine derivatives as potential adenosine A1 and A2A receptor antagonists. Background and rationale - Parkinson’s disease is the ...

    • In silico modelling in the development of novel radiolabelled peptide probes 

      Kleynhans, Janke; Cloete, Theunis; Zeevaart, Jan Rijn; Kruger, Hendrik Gerhardus; Ebenhan, Thomas (Bentham Science, 2020)
      This review describes the usefulness of in silico design approaches in the design of new radiopharmaceuticals, especially peptide-based radiotracers (including peptidomimetics). Although not part of the standard arsenal ...

    • Non-oncological applications of RGD-based single-photon emission tomography and positron emission tomography agents 

      Ebenhan, Thomas; Zeevaart, Jan Rijn; Kleynhans, Janke; Jeong, Jae Min; Sathekge, Mike (Springer, 2020)
      Introduction Non-invasive imaging techniques (especially single-photon emission tomography and positron emission tomography) apply several RGD-based imaging ligands developed during a vast number of preclinical and clinical ...

    • Radiopharmaceutical enhancement by drug delivery systems: a review 

      Kleynhans, Janke; Grobler, Anne Frederica; Zeevaart, Jan Rijn; Ebenhan, Thomas; Sathekge, Mike Machaba (Elsevier, 2018)
      Introduction Drug delivery systems are entities designed to alter the biological behaviour of the pharmaceutical active ingredients that they carry in order to afford more beneficial biodistribution and safety profiles. ...