Browsing by Author "Kotzé, Awie F."
Now showing items 1-9 of 9
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Absorption of the novel artemisinin derivatives artemisone and artemiside: potential application of Pheroid™ technology
Steyn, J. Dewald; Du Plessis, Lissinda H.; Grobler, Anne F.; Kotzé, Awie F.; Haynes, Richard K. (Elsevier, 2011)Artemisinins have low aqueous solubility that results in poor and erratic absorption upon oral administration. The poor solubility and erratic absorption usually translate to low bioavailability. Artemisinin-based monotherapy ... -
Applications of lipid based formulation technologies in the delivery of biotechnology-based therapeutics
Du Plessis, Lissinda H.; Marais, Etienne B.; Mohammed, Faruq; Kotzé, Awie F. (Bentham Science, 2014)In the last decades several new biotechnologically-based therapeutics have been developed due to progress in genetic engineering. A growing challenge facing pharmaceutical scientists is formulating these compounds into ... -
Direct compression of chitosan: process and formulation factors to improve powder flow and tablet performance
Buys, Gerhard M.; Du Plessis, Lissinda H.; Marais, Andries F.; Kotzé, Awie F.; Hamman, Josias H. (Bentham Science, 2013)Chitosan is a polymer derived from chitin that is widely available at relatively low cost, but due to compression challenges it has limited application for the production of direct compression tablets. The aim of this study ... -
Effect of moisture content, temperature and exposure time on the physical stability of chitosan powder and tablets
Viljoen, Joe M.; Steenekamp, Jan H.; Marais, Andries F.; Kotzé, Awie F. (Taylor & Francis, 2014)Context: Chitosan does not rank highly regarding its employment as tablet filler due to certain limitations. Undesirable properties that limit its utilization as excipient in solid dosage forms include its hydration ... -
Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria
Du Plessis, Lissinda H.; Helena, Chrizaan; Van Huyssteen, Este; Kotzé, Awie F.; Wiesner, Lubbe (Wiley, 2014)Objectives Mefloquine (MQ) is an antimalarial drug with high efficacy, often used in the treatment and chemoprophylaxis of malaria. However, it has low solubility in water, a long elimination half-life (4 days), and is ... -
In vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparum
Du Plessis, Lissinda H.; Van Niekerk, Anel C.; Maritz, Marlene M.; Kotzé, Awie F. (Springer Nature, 2012)The macrolide antibiotics, erythromycin and azithromycin, have been studied for their potential antimalarial activity, but only modest activity has been demonstrated. In this study, we investigated the enhancement of the ... -
Intestinal drug absorption enhancers: synergistic effects of combinations
Enslin, Gill M.; Kotzé, Awie F.; Hamman, Josias H. (Taylor & Francis, 2008)Although many absorption enhancers have been investigated, very few are used clinically. A need exists therefore for more effective absorption enhancers. The drug-absorption-enhancing effects of combinations of N-trimethyl ... -
Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride
Du Plessis, Lissinda H.; Kotzé, Awie F.; Junginger, Hans E. (Taylor & Francis, 2010)The aim of this study was to evaluate the ability of TMC, with different degrees of quaternization, to increase insulin absorption in vivo following nasal and rectal administration in rats. Two batches of TMC with different ... -
Peroral and nasal delivery of insulin with PheroidTM technology
Oberholzer, Ian Dewald (North-West University, 2009)Since its initial discovery in 1922 by Banting and Best, the formulation of an oral insulin delivery system has ever been so troublesome. Unfortunately, insulin is indispensable in the treatment of diabetes mellitus, which ...