Browsing by Author "Kruger, R."
Now showing items 1-16 of 16
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8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: the SABPA study
Mels, C.M.C.; Schutte, A.E.; Schutte, R.; Pretorius, P.J.; Smith, W.; Huisman, H.W.; Van der Westhuizen, F.H.; Fourie, C.M.T.; Van Rooyen, J.M.; Kruger, R.; Louw, R.; Malan, N.T.; Malan, L. (Taylor & Francis, 2014)Various studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG). The aim of this study ... -
Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study
Kruger, R.; Schutte, R.; Huisman, H.W.; Van Rooyen, J.M.; Malan, N.T.; Fourie, C.M.T.; Louw, R.; Van der Westhuizen, F.H.; Van Deventer, C.A.; Malan, L.; Schutte, A.E. (Springer Nature, 2012)Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory ... -
Cardiac troponin T as early marker of subclinical cardiovascular deterioration in black hypertensive women
Kruger, R.; Schutte, A.E.; Mels, C.M.C.; Smith, W.; Van Rooyen, J.M.; Kruger, I.M.; Fourie, C.M.T. (Elsevier, 2017)Background Hypertensive heart disease is a rising concern, especially among black South African women. As high sensitivity cardiac troponin T (cTnT) is a marker of cardiomyocyte damage, we determined the potential link ... -
Compromised bioavailable IGF-1 of black men relates favourably to ambulatory blood pressure: the SABPA study
Schutte, A.E.; Schutte, R.; Smith, W.; Huisman, H.W.; Mels, C.M.C.; Malan, L.; Fourie, C.M.T.; Malan, N.T.; Van Rooyen, J.M.; Kruger, R. (Elsevier, 2014)Objectives Insulin-like growth factor-1 (IGF-1) has potent endothelial-protective, anti-platelet and anti-thrombotic activities, and also exerts mitogenic and proliferatory actions on vascular smooth muscle cells. Conflicting ... -
Does smoking impact on the association between oxidative stress and vascular function in young normotensives? the African-Predict study
Mothae, M.M. (North-West University (South-Africa), 2016)Cigarette smoking is one of the most important modifiable risk factors for the development of cardiovascular disease (CVD). Smoking not only plays a role in the onset of CVD, but it has a significant contribution to disease ... -
Evaluation of waist-to-height ratio to predict 5 year cardiometabolic risk in sub-Saharan African adults
Ware, L.J.; Kruger, H.S.; Kruger, I.M.; Greeff, M.; Fourie, C.M.T.; Huisman, H.W.; Scheepers, J.D.W.; Uys, A.S.; Kruger, R.; Van Rooyen, J.M.; Schutte, R.; Schutte, A.E. (Open Access, 2014)Background and aims Simple, low-cost central obesity measures may help identify individuals with increased cardiometabolic disease risk, although it is unclear which measures perform best in African adults. We aimed to: ... -
Exploring a marker of cardiac fibrosis and its association with soluble uPAR in a bi–ethnic South African population : the SAfrEIC study
Du Plooy, Christine Susara (2013)Background: Fibulin-1, an extracellular matrix component and mediator in cardiac fibrosis, is expressed in cardiac valves, heart muscles and blood vessels and may contribute to different cardiovascular pathological ... -
Extracellular matrix biomarker, fibulin-1, is closely related to NT-proBNP and soluble urokinase plasminogen activator receptor in patients with aortic valve stenosis (The SEAS study)
Kruger, R.; Rasmussen, L.M.; Eugen-Olsen, J.; Nielsen, O.W.; Blyme, A. (2014-07-11)Background: Fibulin-1, a circulating extracellular matrix glycoprotein, has been associated with arterial disease and elevated N-terminal prohormone B-type natriuretic peptide (NT-proBNP) in diabetes. Soluble urokinase ... -
Left ventricular structure and urinary metabolomics in young adults: the African- PREDICT study
De Beer, Dalene (North-West University (South-Africa), 2019)Motivation - African populations are more prone to the development of left ventricular structure abnormalities and dysfunction, however limited information exists on potential metabolic pathways contributing to early left ... -
Morning blood pressure surge and its association with arterial function and subclinical target organ damage in young South Africans : the African-PREDICT study
Mokwatsi, Gontse Gratitude (North-West University (South-Africa), 2019)Motivation - The accurate measurement of blood pressure remains the most essential technique for the diagnosis and management of hypertension. In addition, there is increasing evidence that the measurement of clinic blood ... -
Myeloperoxidase and the vasculature in young adults : the African-PREDICT study
Brelage, Annica (North-West University (South-Africa), 2020)Background and motivation: Myeloperoxidase (MPO) is an enzyme with both pro-inflammatory and pro-oxidative functions. Previous studies in the United States have found MPO levels to be higher in African American than in ... -
Nitric oxide bioavailability and cardiovascular function in children and young adults
Craig, A. (North-West University (South Africa), 2020)Background and motivation: The global burden of cardiovascular disease (CVD) including hypertension is ever-increasing, especially in the South African context. Nitric oxide (NO) plays a vital role in normal vascular ... -
NT-proBNP is associated with fibulin-1 in Africans: The SAfrEIC study
Kruger, R.; Schutte, R.; Huisman, H.W.; Schutte, A.E.; Argraves, W.S.; Rasmussen, L.; Olsen, M.D. (Elsevier, 2012)Objectives The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is involved in the regulation of volume load and secreted when systemic cardiac overload occurs. Fibulin-1 on the other hand is a component of ... -
Recent advances in understanding hypertension development in sub-Saharan Africa
Schutte, A.E.; Botha, S.; Fourie, C.M.T.; Gafane-Matemane, L.F.; Kruger, R.; Lammertyn, L.; Malan, L.; Mels, C.M.C.; Schutte, R.; Smith, W.; Van Rooyen, J.M.; Ware, L.J.; Huisman, H.W. (Nature, 2017)Consistent reports indicate that hypertension is a particularly common finding in black populations. Hypertension occurs at younger ages and is often more severe in terms of blood pressure levels and organ damage than in ... -
The role of endothelin-1 in cardiometabolic and vascular function in a bi-ethnic population : the SABPA study
Du Plooy, Christine Susara (North-West University (South Africa) , Potchefstroom Campus, 2017)Motivation The black population in South Africa has a high prevalence of hypertension and atherosclerosis. Endothelin-1 (ET-1), a potent vasoconstrictor peptide, has been implicated as an important biomarker in the ... -
Urinary albumin excretion from spot urine samples predict all-cause and stroke mortality in Africans
Schutte, R.; Schmieder, R.E.; Huisman, H.W.; Smith, W.; Van Rooyen, J.M.; Fourie, C.M.T.; Kruger, R.; Uys, L.; Ware, L.; Mels, C.M.C.; Greeff, M; Kruger, I.M.; Schutte, A.E. (Oxford University Press, 2014)BACKGROUND: Increased urinary albumin excretion reflects general vascular damage and predicts adverse cardiovascular and renal outcomes. Albuminuria can be determined from easily collected spot urine samples, especially ...