Browsing by Author "Malan, Linda"
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Adjusting haemoglobin values for altitude maximizes combined sensitivity and specificity to detect iron deficiency among women of reproductive age in Johannesburg, South Africa
Silubonde, Takana Mary; Baumgartner, Jeannine; Malan, Linda; Smuts, Cornelius Matheus; Ware, Lisa Jayne (MDPI, 2020)In South Africa, haemoglobin (Hb) is measured to screen for iron deficiency (ID). However, low levels of Hb are only a late stage indicator of ID. Furthermore, Hb values are generally not adjusted for altitude even though ... -
Anthropometric nutritional status of children (0–18 years) in South Africa 1997–2022: a systematic review and meta-analysis
Kruger, Herculina Salome; Visser, Marina; Malan, Linda; Zandberg, Lizelle; Wicks, Mariaan; Ricci, Cristian; Faber, Mieke (Cambridge University Press, 2023-10)Objective: To conduct a comprehensive systematic review and meta-analysis of the available literature on the anthropometric nutritional status of South African infants and children, 0–18 years old and to report on trends ... -
Breast milk and erythrocyte fatty acid composition of lactating women residing in a peri‑urban South African township
Siziba, Linda P.; Chimhashua, Tsitsi; Siro, Sicelosethu S.; Jacobs, Adriaan; Malan, Linda; Smuts, Cornelius M.; Baumgartner, Jeannine (Elsevier, 2020)Data on breast milk fatty acid (FA) composition in South African lactating women in relation to their FA status, as well as on potential compositional changes within feed, are limited. The aim of this study was to assess ... -
Combined deficiency of iron and (n-3) fatty acids in male rats disrupts brain monoamine metabolism and produces greater memory deficits than iron deficiency or (n-3) fatty acid deficiency alone1-3
Baumgartner, Jeannine; Smuts, Cornelius M.; Malan, Linda; Arnold, Myrtha; Yee, Benjamin K. (American Society of Nutrition (ASN), 2012)Deficiencies of iron (Fe) (ID) and (n-3) fatty acids (FA) [(n-3)FAD] may impair brain development and function through shared mechanisms. However, little is known about the potential interactions between these 2 common ... -
Comparison of test performance of two commonly used multiplex assays to measure micronutrient and inflammatory markers in serum: results from a survey among pregnant women in South Africa
Chimhashu, Tsitsi; Verhoef, Hans; Symington, Elizabeth; Zandberg, Lizelle; Baumgartner, Jeannine; Malan, Linda; Smuts, Cornelius; Feskens, Edith; Melse-Boonstra, Alida (Cambridge University Press, 2024)The combined sandwich-ELISA (s-ELISA; VitMin Lab, Germany) and the Quansys Q-Plex™ Human Micronutrient Array (7-Plex) are multiplex serum assays that are used to assess population micronutrient status in low-income ... -
Determining sample size adequacy for animal model studies in nutrition research: limits and ethical challenges of ordinary power calculation procedures
Ricci, Cristian; Baumgartner, Jeannine; Malan, Linda; Smuts, Cornelius M. (Taylor & Francis, 2020)Animal models are widely used in the field of nutrition research. Scientifically and ethically sound experiments need an adequate number of experimental units. The use of 5-10 units is common, but such sample sizes can be ... -
The effect of omega-3 fatty acid status on lung inflammation in tuberculosis- infected mice
King, S. (North-West University (South-Africa), 2021)Background: Tuberculosis (TB) bacilli successfully survive within the host. It causes an immune response that is defensive but also harmful to the host’s lung tissue, because of perpetuating inflammation. Non-resolving ... -
The effect of pre-infection omega-3 fatty acid status on anaemia of infection and morbidity in tuberculosis infected mice
Britz, Melinda (North-West University (South-Africa), 2019)Background: Tuberculosis (TB) is currently a major health problem worldwide, and despite improvement, mortality rates are not ideal. Since the immune response, underlying protection against TB is incompletely understood, ... -
Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial
Smuts, Cornelius M.; Matsungo, Tonderayi M.; Malan, Linda; Kruger, Herculina S.; Rothman, Marinel; Covic, Namukolo; Joosten, Karen; Lombard, Carl J.; Faber, Mieke (Oxford Univ Press, 2019)Background Evidence on the effect of small-quantity lipid-based nutrient supplements (SQ-LNSs) on early child growth and development is mixed. Objective This study assessed the effect of daily consumption of 2 different ... -
The effects of anti-inflammatory agents as host-directed adjunct treatment of tuberculosis in humans: a systematic review and meta-analysis
Hayford, Frank Ekow Atta; Dolman, Robin Claire; Nienaber, Arista; Smuts, Cornelius Mattheus; Malan, Linda; Ricci, Cristian (BMC, 2020)Background The potential role of adjunctive anti-inflammatory therapy to enhance tuberculosis (TB) treatment has recently received increasing interest. There is, therefore, a need to broadly examine current host-directed ... -
Effects of egg as an early complementary food on growth of 6- to 9-month-old infants: a randomised controlled trial
Ricci, Hannah; Faber, Mieke; Ricci, Cristian; Kruger, Herculina S.; Malan, Linda; Nakiranda, Regina; Visser, Marina; Smuts, Cornelius Marius (Cambridge University Press, 2023)Objective: To assess the effect of daily egg consumption for six months on linear growth (primary outcome), weight-for-age, weight-for-length, mid-upper arm circumference-for-age, head circumference-for-age Z-scores, ... -
Effects of iron and n-3 fatty acid supplementation, alone and in combination, on cognition in school children: a randomized, double-blind, placebo-controlled intervention in South Africa
Baumgartner, Jeannine; Smuts, Cornelius Mattheus; Malan, Linda; Kvalsvig, Jane; Van Stuijvenberg, M.; Hurrell, Richard; Zimmermann, Michael B. (American Society for Nutrition (ASN), 2012)Background: Little is known about the combined effects of iron and n−3 (omega-3) fatty acid (FA) supplementation on cognitive performance. The provision of either DHA/EPA or iron alone in rats with combined iron and n−3 ... -
Effects of iron and omega-3 supplementation on the immune system of iron deficient children in South Africa : a randomised controlled trial
Malan, Linda (2014)Background Iron deficiency (ID) is the world‟s most prevalent micronutrient deficiency and predominantly affects developing countries, also South Africa. In areas with low fish consumption and high n-6 PUFA vegetable oil ... -
Effects of n-3 polyunsaturated fatty acid and iron deficiency, alone and in combination, during early development on colonic inflammation in rats
Schoeman, Venessa (North-West University (South-Africa), 2019)Background: It has been shown that poor nutrition during early development has a causal relationship with adverse pregnancy outcomes, morbidity, mortality and the increased risk of short- and long-term adverse health ... -
Effects of zinc fortification on the plasma fatty acid composition of Beninese school children : a randomised, double-blind controlled trial
Chimhashu, Tsitsi Letwin (North-West University (South Africa) , Potchefstroom Campus, 2016)Introduction The lack of a specific and sensitive zinc (Zn) status biomarker is problematic. The linoleic acid: dihomo-γ-linolenic acid (LA:DGLA) ratio has been suggested by some researchers to be a Zn status marker. This ... -
Exercise-induced lipid mediator inflammatory signalling in male recreational runners versus untrained males considering potential modulating factors
Bezuidenhout, Erika (North-West University (South-Africa), 2019)Background: Resistance exercise can cause inflammation and it is known that inflammation is closely related to oxidative stress. Oxidative stress can be defined as an imbalance between free radicals and anti-oxidative ... -
Genetic characterisation of delta-5 and delta-6 fatty acid desaturases and associations with fatty acid status in pregnant women of African descent
Prinsloo, Anika (North-West University (South-Africa), 2021)Introduction and aim - Globally, dietary habits have shifted over the years from a traditional rural diet to a more Westernised diet. This has caused a drastic change in the intake ratio of n-6:n-3 polyunsaturated fatty ... -
In male rats with concurrent iron and (n-3) fatty acid deficiency, provision of either iron or (n-3) fatty acids alone alters monoamine metabolism and exacerbates the cognitive deficits associated with combined deficiency 1-3
Baumgartner, Jeannine; Smuts, Cornelius M.; Malan, Linda; Arnold, Myrtha; Yee, Benjamin K.; Yee, Benjamin K. (American Society of Nutrition (ASN), 2012)Concurrent deficiencies of iron (Fe) (ID) and (n-3) fatty acids [(n-3)FAD)] in rats can alter brain monoamine pathways and impair learning and memory. We examined whether repletion with Fe and DHA/EPA, alone and in ... -
Infanticide and its relationship with postpartum psychosis : a critical interpretive synthesis
Jansen van Rensburg, Nicole (North-West University (South-Africa), 2019)Homicide is the cause of death in one in five deaths related to injury globally in children aged younger than five years (Child Trends, 2015). Infanticide is defined as the homicide of an infant within its first year of ... -
Iron status in relation to morbidity when considering iron supplementation among urban pregnant women in South Africa
Goodchild, C. (North-West University, 2018)Background: Anaemia is a common and challenging nutritional problem worldwide and iron deficiency (ID) contributes to about half of all anaemia. In 2002, ID anaemia was considered to be one of the most important contributing ...