Now showing items 1-5 of 5

    • Affinity of dihydropyrimidone analogues for adenosine A1 and A2A receptors 

      Katsidzira, Runako Masline (2014)
      Parkinson’s disease (PD) is a neurodegenerative disorder that is characterised by a reduction of dopamine concentration in the striatum due to degeneration of dopaminergic neurons in the substantia nigra. Currently, first ...
    • Inhibition of monoamine oxidase B by N-methyl-2-phenylmaleimides 

      Manley-King, Clarina I.; Terre'Blanche, Gisella; Castagnoli, Neal; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2009)
      Based on a recent report that 1-methyl-3-phenylpyrrolyl analogues are moderately potent reversible inhibitors of the enzyme monoamine oxidase B (MAO-B), a series of structurally related N-methyl-2-phenylmaleimidyl analogues ...
    • Inhibition of monoamine oxidase by (E)-styrylisatin analogues 

      Van der Walt, Elizna M.; Milczek, Erika M.; Malan, Sarel F.; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2009)
      Previous studies have shown that (E)-8-(3-chlorostyryl)caffeine (CSC) is a specific reversible inhibitor of human monoamine oxidase B (MAO-B) and does not bind to human MAO-A. Since the small molecule isatin is a natural ...
    • Monoamine oxidase inhibition by selected anilide derivatives 

      Bergh, Jacobus Johannes; Kruger, Johann; Legoabe, Lesetja Jan; Petzer, Jacobus Petrus; Petzer, Anél (Elsevier, 2011)
      A series of anilide derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The most potent inhibitors among the derivatives that were initially evaluated were ...
    • The synthesis and evaluation of 1-methyl-3-pyrrolines and 1-methylpyrroles as substrates and inhibitors of monoamine oxidase B 

      Ogunrombi, Modupe Olufunmilayo (North-West University, 2007)
      Very little is known about why and how the Parkinson's disease (PD) neurodegenerative process begins and progresses. In the course of developments for treatment of PD, the discovery of the inhibition of monoamine oxidase ...