Browsing by Author "Smith, Wayne"
Now showing items 1-20 of 22
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Autonomic activity and its relationship with the endogenous cardiotonic steroid marinobufagenin: the African-PREDICT study
Strauss, Michél; Smith, Wayne; Schutte, Aletta E.; Wei, Wen; Fedorova, Olga V. (Taylor & Francis, 2020)Aim: Marinobufagenin (MBG), a cardiotonic steroid and a natriuretic hormone, is elevated in response to high salt diet consumption. In animal models salt intake stimulates adrenocortical MBG secretion via increased angiotensin ... -
Brain-derived-neurotrophic-factor, dynamic retinal vessel responses during flicker light and stroke risk: the SABPA study
Wentzel, Annemarie; Malan, Leoné; Von Känel, Roland; Smith, Wayne; Malan, Nicolaas (Karger, 2019)Assessment of the retinal vessels’ structure and function provides an automated and objective approach to noninvasively assess the condition of the cerebral microvasculature and indicates susceptibility for stroke. ... -
The cardiotonic steroid marinobufagenin is a predictor of increased left ventricular mass in obesity: the African-PREDICT study
Strauss-Kruger, Michél; Kruger, Ruan; Smith, Wayne; Gafane-Matemane, Lebo F.; Mokwatsi, Gontse; Schutte, Aletta E. (MDPI, 2020)The endogenous Na+/K+-ATPase inhibitor, marinobufagenin (MBG), strongly associates with salt intake and a greater left ventricular mass index (LVMi) in humans and was shown to promote cardiac fibrosis and hypertrophy in ... -
Carotid cross-sectional wall area is significantly associated with serum leptin levels, independent of body mass index: the SABPA studyent of body mass index: the SABPA study
Mels, Catharina Martha Cornelia; Pieterse, Chiné; Schutte, Aletta Elisabeth; Schutte, Rudolph; Smith, Wayne (Japanese Society of HypertensionNature Publishing Group, 2012)Hypertension and obesity are serious health burdens in sub-Saharan Africa. Urbanized Africans seem to be more susceptible to the development of these diseases than Caucasians. Current research suggests that leptin may be ... -
Correction to: Heart rate variability, the dynamic nature of the retinal microvasculature and cardiac stress: providing insight into the brain–retina–heart link: the SABPA study
Wentzel, Annemarie; Malan, Leoné; Von Känel, Roland; Smith, Wayne; Malan, Nicolaas T. (Springer, 2020)Correction to: Eye https://doi.org/10.1038/s41433-019-0515-y Since the online publication of this article, the authors have noticed that the conclusion to the abstract contains an error. The correct abstract conclusion ... -
The Exercise, Arterial Modulation and Nutrition in Youth South Africa Study (ExAMIN Youth SA)
Kruger, Ruan; Monyeki, Makama Andries; Schutte, Aletta Elisabeth; Smith, Wayne; Mels, Catharina Martha Cornelia; Kruger, Herculina Salomé; Pienaar, Anita Elizabeth; Gafane-Matemane, Lebo Francina; Breet, Yolandi; Lammertyn, Leandi; Mokwatsi, Gontse Gratitude; Kruger, Ankebé; Deacon, Elmari (Frontiers Media, 2020)Background: The impact of a sedentary and unhealthy lifestyle on cardiovascular health is well-documented, however the current obesity and hypertension trends among children is concerning. The ExAMIN Youth SA study aims ... -
Heart rate variability and the dynamic nature of the retinal microvasculature: providing insight into the brain-retina-heart link: the SABPA study
Wentzel, Annemarie; Malan, Leoné; Von Känel, Roland; Smith, Wayne; Malan, Nicolaas (Karger, 2019)Controversy exists regarding the contribution of the autonomic nervous system (ANS) to the retinal microvasculature’s autoregulatory capacities. It was demonstrated that mean retinal vessel responses to systemic sympathetic ... -
Heart rate variability, the dynamic nature of the retinal microvasculature and cardiac stress: providing insight into the brain-retina-heart link: the SABPA study + Correction
Wentzel, Annemarie; Malan, Leoné; Von Känel, Roland; Smith, Wayne; Malan, Nicolaas T. (Nature, 2020)Background and aims Decreased heart-rate-variability (HRV) indicates increased sympathetic nervous system (SNS) activity and modulation with a shift in the sympatho-vagal balance towards SNS predominance. Increased SNS ... -
L-Carnitine and long-chain acylcarnitines are positively correlated with ambulatory blood pressure in humans: the SABPA study
Mels, Catharina M. C.; Schutte, Aletta E.; Erasmus, Elardus; Huisman, Hugo W.; Schutte, Rudolph; Fourie, Carla M.T.; Kruger, Ruan; Van Rooyen, Johannes M.; Smith, Wayne; Malan, Nicolaas T.; Malan, Leoné (Springer, 2013)The prevalence of hypertension in sub-Saharan Africa is increasing rapidly, and treatment remains challenging. Although the use of l-carnitine in treatment has received much attention, studies reporting on physiological ... -
Left ventricular structure and function and the link with oxidative stress in young adults : The African-PREDICT study
Hawley, Lee Ann Charlotte (North-West University (South-Africa). Potchefstroom Campus, 2019)In developed counties, the contribution of cardiovascular diseases (CVDs) to morbidity and mortality rates is well documented. In a study conducted in South Africa (N=4506), it was found that 92% of the study population ... -
Leptin and the retinal microvasculature in young black and white adults: the African-PREDICT study
Ahiante, Blessing Osemengbe; Smith, Wayne; Lammertyn, Leandi; Schutte, Aletta Elisabeth (Elsevier, 2020)Background Leptin is a vasoactive peptide that has been linked to diseases associated with macrovascular deterioration. What is still uncertain is its involvement in the microvasculature. Since microvascular changes are ... -
Low serum testosterone and increased diastolic ocular perfusion pressure: a risk for retinal microvasculature
Malan, Nico T.; Smith, Wayne; Von Känel, Roland; Hamer, Mark; Schutte, Alta E.; Malan, Leoné (Verlag Hans Huber Hogrefe Ag, 2015)Summary: Background: Low levels of testosterone in men and changes in retinal microvascular calibre are both associated with hypertension and cardiovascular disease risk. Sex hormones are also associated with blood flow ... -
Low testosterone and hyperkinetic blood pressure responses in a cohort of South African men: the SABPA study
Malan, Nicolaas T.; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Schutte, Rudolph; Mels, Catharina M.; Steyn, Hendrik S.; Smith, Wayne; Fourie, Carla M.; Glyn, Matthew; Malan, Leoné (Taylor & Francis, 2013)Hypertension (HT) and the metabolic syndrome are major problems in Africa. The role of sex hormones in the cardiovascular profile of black Africans in South Africa has not been studied. Our objective was to study the ... -
Marinobufagenin and markers of early cardiovascular risk in a young black and white population: The African-PREDICT study
Strauss, Michél (North-West University (South-Africa). Potchefstroom Campus, 2019)There have been many arguments about the harmful effect of increased or low salt intake and its concurrent role in cardiovascular health. While an overwhelming amount of research has focused on the relationship between ... -
Microvascular function in non-dippers: potential involvement of the salt sensitivity biomarker, marinobufagenin-the African-PREDICT study
Strauss-Kruger, Michél; Smith, Wayne; Schutte, Aletta E.; Wei, Wen; Bagrov, Alexei Y. (Wiley, 2020)Suppressed nighttime blood pressure dipping is associated with salt sensitivity and may increase the hemodynamic load on the microvasculature. The mechanism remains unknown whereby salt sensitivity may increase the ... -
The oxidative stress profile and its relation to vascular function in a bi-ethnic cohort: the SABPA study
Huisman, Hugo; Mels, Catharina; Kruger, Ruan; Smith, Wayne; Du Plooy, Christine (Karger, 2019)Oxidative stress and inflammation has been implicated in arterial stiffness, and hypertension development. Oxidative stress may interfere with normal vascular function by inactivation of NO and/or the production of ... -
Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study
Ramoshaba, Nthai E.; Huisman, Hugo W.; Lammertyn, Leandi; Schutte, Aletta E.; Smith, Wayne (Springer Nature, 2020)Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether ... -
Retinal vessel caliber and caliber responses in true normotensive black and white adults: the African-PREDICT study
Smith, Wayne; Lammertyn, Leandi; Ramoshaba, Nthai E.; Huisman, Hugo W.; Schutte, Aletta E. (Elsevier, 2020)Purpose Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis ... -
Retinal vessel calibres and haemostasis in black and white South Africans: the SABPA study
Lammertyn, Leandi; Schutte, Aletta E.; Smith, Wayne; Pieters, Marlien; Schutte, Rudolph (Lippincott Williams & Wilkins, 2015)Objectives: Retinal arteriolar narrowing associates with hypertension development and indicates increased cardiovascular risk. Evidence on whether the retinal vessel "calibres are related to the haemostatic system is ... -
Sex hormones associated with subclinical kidney damage and atherosclerosis in South African men: the SABPA study
Malan, Nico T.; Hamer, Mark; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Mels, Catharina M.; Smith, Wayne; Fourie, Carla M.T.; Schutte, Rudolph; Kruger, Ruan; Malan, Leoné (Kluwer, 2012)Background: Hypertension and increased blood glucose are associated with subclinical kidney damage, atherosclerosis and with low testosterone values. Low testosterone in men is often accompanied by increased levels of ...