Browsing by Subject "Sweetana-Grass diffusion cells"
Now showing items 1-4 of 4
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Comparison of rat and porcine jejunum as in vitro models for P–glycoprotein mediated efflux using the Sweetana–Grass diffusion method
(North-West University, 2010)Absorption of drug substances across the intestinal epithelium is a complex and dynamic process. Counter transport proteins are responsible for the efflux of specific drug molecules after they have been absorbed. One of ... -
The effect of different modulators on the transport of rhodamine 123 across rat jejunum using the sweetana-grass diffusion method
(North-West University, 2004)P-glycoprotein (Pgp), which leads to multidrug resistance in tumour cells, is an ATP-dependent secretory drug efflux pump. In the intestine, as well as at specific other epithelial and endothelial sites, P-glycoprotein ... -
The effect of selected hydroxy flavonoids on the in vitro efflux transport of rhodamine 123 using rat jejunum
(North-West University, 2005)Background: Multidrug resistance (MDR) is resistance of cancer cells to multiple classes of chemotherapeutic drugs that can be structurally unrelated. MDR involves altered membrane transport that results in a lower cell ... -
The effect of selected methoxy flavonoids on the in vitro efflux transport of rhodamine 123 using rat jejunum
(North-West University, 2005)Many orally administered drugs must overcome several barriers before reaching their target site. The first major obstacle to cross is the intestinal epithelium. Although lipophilic compounds may readily diffuse across the ...