Browsing by Subject "Treatment failure"
Now showing items 1-6 of 6
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The altered urine metabolome induced by DOTS therapy in pulmonary tuberculosis patients
(North-West University (South Africa), 2023)Metabolomics holds great promise for studying complex diseases like tuberculosis (TB), where treatment outcomes are influenced by a combination of biological, environmental, and social factors. This study aimed to gain a ... -
Blood levels of selective antiretroviral drugs over a period of time, in Sprague-Dawley rats
(North-West University, 2008)Selective antiretroviral (ARV) drugs are primarily metabolized by cytochrome P450 (CYP) enzymes, characteristically predisposed to variation, and are therefore primarily responsible for ARV pharmacokinetic variability and ... -
Characterising tuberculosis and treatment failure thereof using metabolomics
(North-West University, Potchefstroom Campus, 2017., 2017)Tuberculosis (TB), a highly contagious bacterial disease caused by Mycobacterium tuberculosis, is considered the leading cause of death globally from a single bacterial pathogen. The latest reports indicate 10.4 million ... -
Characterising tuberculosis treatment success and failure using metabolomics
(North-West University, 2013)Tuberculosis (TB) is one of the deadliest infectious diseases of our time, with 1.4 million deaths globally, recorded in 2010 (3800 deaths a day) by the World Health Organization (WHO). Currently, South Africa ranks third ... -
Predicting tuberculosis treatment outcome using metabolomics
(Future Medicine, 2017)Aim: Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and ... -
Urinary metabolite markers characterizing tuberculosis treatment failure
(Springer, 2017)Background Considering that approximately 15% of the nine million new tuberculosis (TB) cases reported per annum are not treated successfully, new, distinctive and specific biomarkers are needed to better characterize the ...