Show simple item record

dc.contributor.authorSchutte, Rudolph
dc.contributor.authorThijs, Lutgarde
dc.contributor.authorAsayama, Kei
dc.contributor.authorBoggia, José
dc.contributor.authorLi, Yan
dc.identifier.citationSchutte, R. et al. 2013. Double product reflects the predictive power of systolic pressure in the general population: evidence from 9,937 participants. American iournal of hypertension. 26(5):665-672. []en_US
dc.identifier.issn1941-7225 (Online)
dc.description.abstractBACKGROUND The double product (DP), consisting of the systolic blood pressure (SBP) multiplied by the pulse rate (PR), is an index of myocardial oxygen consumption, but its prognostic value in the general population remains unknown. METHODS We recorded health outcomes in 9,937 subjects (median age, 53.2 years; 47.3% women) randomly recruited from 11 populations and enrolled in the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) study. We obtained the SBP, PR, and DP for these subjects as determined through 24-hour ambulatory monitoring. RESULTS Over a median period of 11.0 years, 1,388 of the 9,937 study subjects died, of whom 536 and 794, respectively, died of cardiovascular (CV) and non-CV causes, and a further 1,161, 658, 494, and 465 subjects, respectively, experienced a CV, cardiac, coronary, or cerebrovascular event. In multivariate-adjusted Cox models, not including SBP and PR, DP predicted total, CV, and non-CV mortality (standardized hazard ratio [HR], ≥ 1.10; P ≤ 0.02), and all CV, cardiac, coronary, and stroke events (HR, ≥ 1.21; P < 0.0001). For CV mortality (HR, 1.34 vs. 1.30; P = 0.71) and coronary events (1.28 vs. 1.21; P = 0.26), SBP and the DP were equally predictive. As compared with DP, SBP was a stronger predictor of all CV events (1.39 vs. 1.27; P = 0.002) and stroke (1.61 vs. 1.36; P < 0.0001), and a slightly stronger predictor of cardiac events (1.32 vs. 1.22; P = 0.06). In fully adjusted models, including both SBP and PR, the predictive value of DP disappeared for fatal endpoints (P ≥ 0.07), coronary events (P = 0.06), and stroke (P = 0.12), or DP was even inversely associated with the risk of all CV and cardiac events (both P ≤ 0.01). CONCLUSION In the general population, we did not observe DP to add to risk stratification over and beyond SBP and PR.en_US
dc.publisherOxford University Press
dc.subjectBlood pressureen_US
dc.subjectdouble producten_US
dc.subjectsystolic blood pressureen_US
dc.subjectcardiovascular risken_US
dc.subjectgeneral populationen_US
dc.titleDouble product reflects the predictive power of systolic pressure in the general population: evidence from 9,937 participantsen_US
dc.contributor.researchID12201405 - Schutte, Rudolph

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record