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dc.contributor.authorLemmer, Hendrik J.R.
dc.contributor.authorHamman, Josias H.
dc.identifier.citationLemmer, H.J.R. & Hamman, J.H. 2013. Paracellular drug absorption enhancement through tight junction modulation. Expert opinion on drug delivery, 10(1):103-114. []en_US
dc.identifier.issn1744-7593 (Online)
dc.description.abstractIntroduction: Inclusion of absorption-enhancing agents in dosage forms is one approach to improve the bioavailability of active pharmaceutical ingredients with low membrane permeability. Tight junctions are dynamic protein structures that form a regulated barrier for movement of molecules through the intercellular spaces across the intestinal epithelium. Some drug absorption enhancers are capable of loosening tight junctions and thereby facilitate paracellular absorption of drug molecules. Areas covered: The physiology of tight junctions as well as the mechanisms through which tight junctions can be modulated is discussed. Selected tight junction modulators are specifically described including chelating agents (e.g., ethylenediaminetetraacetic acid), cationic polymers (e.g., chitosan and derivatives), toxins (e.g., zonula occludens toxin), and plant-derived materials (e.g., Aloe vera gel). Expert opinion: As more and more drugs are developed with low membrane permeability, new interest is generated in finding ways to enhance their absorption. The progress made in comprehending the function and structure of tight junctions has contributed to advances in terms of enhanced drug delivery through the paracellular pathway. Although tight junction modulation holds great potential for effective oral delivery of poorly absorbable drugs, many challenges still need to be overcome before more clinically successful formulations could be produced Read More:
dc.publisherTaylor & Francisen_US
dc.subjectAbsorption enhancementen_US
dc.subjectParacellular pathwayen_US
dc.subjectTight junctionen_US
dc.subjectZonula occludens toxinen_US
dc.titleParacellular drug absorption enhancement through tight junction modulationen_US
dc.contributor.researchID10081097 - Hamman, Josias Hendrik
dc.contributor.researchID12932574 - Lemmer, Hendrik Jacobus Righard

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