Artemisone inhibits in vitro and in vivo propagation of Babesia bovis and B. bigemina parasites
Date
2013Author
Mazuz, Monica L.
Haynes, Richard K.
Golenser, Jacob
Fish, Leah
Wollkomirsky, Ricardo
Metadata
Show full item recordAbstract
Artemisone was evaluated, in in vitro and in vivo, for control of bovine babesiosis caused by Babesia
bigemina and Babesia bovis parasites. In vitro, artemisone reduced parasitemia in a dose-dependent manner:
the inhibitory effects increased gradually, reaching a maximum inhibition of 99.6% and 86.4% for B.
bigemina and B. bovis, respectively 72 h after initiation of treatment with initial parasitemia of 0.5%. In
calves infected with either B. bigemina or B. bovis artemisone treatment was well tolerated and prevented
development of acute babesiosis in all animals except for one B. bovis-infected calf. The treatment did not
eliminate all blood parasites, and recovered animals carried a persistent low-level infection. Treatment
with artemisone may be useful as an alternative drug for preventing the pathology that results from babesiosis,
without interfering with acquired immune protection following recovery from an acute babesiosis
infection or vaccination.
URI
http://hdl.handle.net/10394/14854https://doi.org/10.1016/j.exppara.2013.10.006
https://www.sciencedirect.com/science/article/pii/S0014489413002713
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- Faculty of Health Sciences [2386]