Depressive symptoms and 24-hour ambulatory blood pressure in Africans: the SABPA study
Date
2012Author
Hamer, Mark
Harvey, Brian H.
Malan, Nico T.
Malan, Leoné
Frasure-Smith, Nancy
Metadata
Show full item recordAbstract
Disturbances in circadian rhythm might play a central role in the neurobiology of depression. We examined the association
between depressive symptoms and 24-hour ambulatory BP in a sample of 405 (197 black and 208 Caucasian) urbanized African
teachers aged 25 to 60 yrs (mean 44.6 ± 9.6 yrs). Depressive symptoms were assessed using the self-administered 9-item Patient
Health Questionnaire (PHQ-9). After adjusting for age, sex, and ethnicity, participants with severe depressive symptoms (PHQ-9
≥ 15) had higher odds of hypertension defined from ambulatory BP and/or use of antihypertensive medication (odds ratio = 2.19,
95% CI, 1.00–4.90) in comparison to participants with no symptoms. Compared to Caucasians with no depressive symptoms,
those with severe symptoms had blunted nocturnal systolic BP drop of 4.7mmHg (95% CI, −0.5 to 10.0, P = 0.07). In summary,
depressive symptoms were associated with the circadian BP profile in black and Caucasian Africans.
URI
http://hdl.handle.net/10394/14869https://www.hindawi.com/journals/ijhy/2012/426803/
https://doi.org/10.1155/2012/426803
Collections
- Faculty of Health Sciences [2386]