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The synthesis and evaluation of 1-methyl-3-pyrrolines and 1-methylpyrroles as substrates and inhibitors of monoamine oxidase B / Modupe O. Ogunrombi

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dc.contributor.author Ogunrombi, Modupe Olufunmilayo
dc.date.accessioned 2009-05-22T09:10:47Z
dc.date.available 2009-05-22T09:10:47Z
dc.date.issued 2007
dc.identifier.uri http://hdl.handle.net/10394/1837
dc.description Thesis (Ph.D. (Pharmaceutical Chemistry))--North-West University, Potchefstroom Campus, 2008.
dc.description.abstract Very little is known about why and how the Parkinson's disease (PD) neurodegenerative process begins and progresses. In the course of developments for treatment of PD, the discovery of the inhibition of monoamine oxidase (MAO B) was a conceptual breakthrough, and has now been firmly established. MAO B has also been implicated in the neurodegenerative processes resulting from exposure to xenobiotic amines. For example, MAO B catalyzes the first step of the bioactivation of the parkinsonian inducing pro-neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Additional insight into the mechanism of catalysis of MAO B and the mechanism of neurotoxicity by MPTP is therefore very valuable in the pursuit of the treatment of PD.
dc.publisher North-West University
dc.subject Monoamine oxidase B en
dc.subject MPTP en
dc.subject 1-methyl-3-phenyl-3-pyrroline en
dc.subject 1-methyl-3-phenyl-3-pyrrole en
dc.subject Neurotoxicity en
dc.subject Dopamine en
dc.subject Striata en
dc.subject Reversible inhibitors en
dc.subject Competitive inhibition en
dc.subject Structure-activity relationship en
dc.title The synthesis and evaluation of 1-methyl-3-pyrrolines and 1-methylpyrroles as substrates and inhibitors of monoamine oxidase B / Modupe O. Ogunrombi en
dc.type Thesis en
dc.description.thesistype Doctoral


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    This collection contains the original digitized versions of research conducted at the North-West University (Potchefstroom Campus)

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