Browsing Research Output by Author "7391bbe6-5293-4d97-b459-d057e78753f1"
Now showing items 1-9 of 9
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Acute changes in haematocrit leading to polycythaemia in late-onset hypogonadism patients that receive testosterone replacement therapy: a South African study
Du Plessis, Jesslee; Bester, Hermanus Lambertus; Julyan, Marlene; Cockeran, Marike (Taylor & Francis, 2019)Background: According to the literature, parenteral testosterone replacement therapy (TRT)-induced polycythaemia is associated with cardiovascular events. No or minimal data exist for the prevalence of TRT-induced ... -
Bias and variance reduction procedures in non-parametric regression
Cockeran, Marike; Swanepoel, Cornelia J. (SASA, 2016)The purpose of this study is to determine the effect of three improvement methods on nonparametric kernel regression estimators. The improvement methods are applied to the Nadaraya-Watson estimator with cross-validation ... -
Chronic disease list conditions in patients with rheumatoid arthritis in the private healthcare sector of South Africa
Olivier, Nericke; Burger, Johanita; Joubert, Rianda; Lubbe, Martie; Naudé, Adele; Cockeran, Marike (Springer, 2018)Introduction Little is known about the burden of rheumatoid arthritis (RA) in South Africa. The aim of this study was to establish the prevalence of RA and coexisting chronic disease list (CDL) conditions in the private ... -
Defensive coping facilitated a smaller cortisol-to-estradiol ratio and a higher hypertension risk: the SABPA study
Malan, Leoné; De Kock, Andrea; Hamer, Mark; Cockeran, Marike; Malan, Nicolaas Theodor (Taylor & Francis, 2018)Objectives: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It ... -
Fluoroquinolone prescribing patterns in the private healthcare sector of South Africa, 2005-2012
Agyakwa, Winifred; Lubbe, Martha S.; Burger, Johanita R.; Cockeran, Marike; Malik, Madeeha; Katende-Kyenda, Norah L. (College of Pharmacists of Buenos Aires Province, Argentina, 2015)Increased prescribing of fluoroquinolones leading to resistance is an issue of concern at present globally. The present study was designed to investigate prescribing patterns for fluoroquinolones in a section of the South ... -
Goodness-of-fit tests in the Cox proportional hazards model
Cockeran, Marike; Meintanis, Simos George; Allison, James S. (Taylor & Francis, 2019)We consider a variety of tests for testing goodness-of-fit in a parametric Cox proportional hazards (PH) model and compare their performance. Aspects of the model under test include the baseline distribution and time-invariance ... -
Longitudinal changes of cardiac troponin and inflammation reflect progressive myocyte stretch and likelihood for hypertension in a Black male cohort: the SABPA study
Jansen van Vuren, Esmé; Malan, Leoné; Von Känel, Roland; Lammertyn, Liandi; Cockeran, Marike; Malan, Nicolaas T. (Springer, 2019)Inflammation was cross-sectionally associated with subclinical wall remodeling and hypertension. Whether longitudinal changes (∆) in inflammation, myocyte injury (troponin T), and stretch (N-terminal-pro-B-type natriuretic ... -
Monitoring the South African population’s salt intake: spot urine v. 24 h urine
Swanepoel, Bianca; Schutte, Aletta E.; Cockeran, Marike; Wentzel-Viljoen, Edelweiss; Steyn, Krisela (Cambridge Univ Press, 2018)Objective The present study set out to determine whether morning spot urine samples can be used to monitor Na (and K) intake levels in South Africa, instead of the ‘gold standard’ 24 h urine sample. Design Participants ... -
Time-to-onset of treatment for hypertension and hyperlipidaemia in South African diabetes mellitus patients: a survival analysis using medicine claims data
Obeng-Kusi, Mavis; Lubbe, Martha Susanna; Cockeran, Marike; Burger, Johanita Riëtte (Wiley, 2019)What is known and objective Hypertension and hyperlipidaemia have high prevalence among diabetics and increase patients’ risk of cardiovascular diseases, ultimately affecting prognosis negatively. Medicine claims data ...