Browsing Research Output by Title
Now showing items 2191-2210 of 13384
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Considerations for an in vitro, cell-based testing platform for detection of adverse drug-induced inotropic effects in early drug development. Part 1: General considerations for development of novel testing platforms
(Frontiers Media, 2019)Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted ... -
Considerations for an in vitro, cell-based testing platform for detection of drug-induced inotropic effects in early drug development. Part 2. Designing and fabricating microsystems for assaying cardiac contractility with physiological relevance using human iPSC-cardiomyocytes
(Frontiers Media, 2019)Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human ... -
Considerations in Grounded Theory Research Method: A reflection on the lessons learned
(2010)This paper is a discussion on the practical issues faced by Information Systems (IS) professionals when they employ Grounded Theory Method (GTM) in Information Systems research. Various strands of GTM are in use, all of ... -
Considerations on the mechanism of action of artemisinin antimalarials. Part 1. The 'carbon radical' and 'heme' hypotheses
(Bentham Science, 2013)The isolation of artemisinin from the traditional medicinal herb qīng hāo (Artemisia annua), its characterization as a peroxide and preparation of the derivatives dihydroartemisinin, artemether and artesunate in the 1970s ... -
Considering complexities in unique African planning approaches: abstracting the role of African urban residents
(WIT Press, 2017)Africa is currently the fastest urbanising region in the world and has subsequently become the centre of continuously growing attention from planning practitioners and academics. Many of these scholars argue for a unique ... -
Considering flood risk in spatial development planning: a land use conflict analysis approach
(AOSIS, 2019)Flooding is the predominant natural hazard observed in Africa, and it often leads to damage to property and losses in human lives. To ensure that the detrimental effects of flooding are kept to a minimum, flood-prone areas ... -
Considering new urbanism, new ruralism and green urbanism in response to multifunctionality: the case of Verkykerskop, South Africa
(WIT Press, 2017)Paul Davidoff charged planners in 1965, as a profession making urban life more beautiful, exciting, creative and more just, as having little to say. The task thereupon was to train a generation of planners to go well ... -
Considering planning approaches in the global south and learning from co-production in South Africa’s informal backyard rental sector
(WIT Press, 2017)The global South has traditionally been regarded as oppressed and subjugated, grappling to reach western ideals on the appropriate, desirable and modern. However, framing the developing world as such, fails to recognise ... -
Considering the influence of human trust in practical social engineering exercises
(IEEE, 2014)There are numerous technical advances in the field of information security. However, the application of information security technologies alone is often not sufficient to address security issues. Human factors play an ... -
Considering the this-worldly religious focus of the African traditional worldview as found in South Africa
(AOSIS, 2017)Most articles evaluating the African traditional worldview focus an attack on the ancestor cult or highlight positive aspects of the worldview. In either case, mention of the this-worldly religious focus tends to be 'in ... -
Conspecific density and environmental complexity impact behaviour of turquoise killifish (Nothobranchius furzeri)
(Wiley, 2020)Fish models are essential for research in many biological and medical disciplines. With a typical lifespan of only 6 months, the Turquoise killifish (Nothobranchius furzeri) was recently established as a time‐ and ... -
A constant reminder from the Revelation of God in the Apocalypse of John about who God is in times when philosophical concepts blur Biblical clarity
(CTBS, 2015)The Exodus from Egypt was a defining moment in the history of Israel. They "were promised nationhood, but that required the sense of being a people, united" in their historical origin, religion and sovereignty over a ... -
Constitutional basis for the enforcement of ''executive'' policies that give effect to socio-economic rights in South Africa
(2013)Although "executive" policies remain an important governance tool, there appears to be confusion on the status and possible basis for their judicial enforcement in South Africa. The aim of this article is to critically ... -
Constitutional conversations in the anthropocene: in search of environmental Jus Cogens Norms
(Springer Link, 2015)This chapter investigates the existence of environmental jus cogens norms and the possibility of extending peremptory norms into the environmental domain. For this purpose, the chapter briefly describes the trite manifestation ... -
Constitutional dialogue and the dialogic constitution (or: Constitutionalism as culture of dialogue)
(Unisa, 2010)A constitution speaks. So my experience as theoretician of constitutional interpretation has taught me. Constitution-speak is not a monologue, not a monolithic soliloquy, with the supreme Constitution simply speaking for ... -
Constitutional interpretation in the so-called 'hard cases': Revisiting S v Makwanyane
(Pretoria University Law Press, 2017)Grondwetlike interpretasie in sogenaamde 'moeilike sake' verg, in sekere gevalle, dat regters van subjektiewe maatstawe moet gebruik maak om definisie te verskaf aan grondwetlike regte en waardes. Dit beteken dat regters ... -
The constitutionalisation of public international law and the creation of an international rule of law: Taking stock
(VerLoren van Themaat Centre for Public Law Studies, 2009) -
Constitutionalism and coloniality: A case of colonialism continued or the best of both worlds?
(School for Basic Sciences, Vaal Triangle Campus, North-West University, 2016)This article deals with the concept of constitutionalism in relation to colonialism and modernity, with a specific emphasis upon South Africa and South African constitutional development. The Republic of South ... -
Constitutionalism, parliamentary condemnation and the South African public protector
(Nomos Verlagsgesellschaft, 2015)The South African Constitution under chapter 9 establishes state institutions that are mandated with the obligation to strengthen the concept of constitutional democracy in the Republic. The Constitution requires that other ... -
Constrained language: a multidimensional analysis of translated English and a non-native indigenised variety of English
(John Benjamins Publishing, 2016)Translation and non-native indigenised varieties of English are produced in contexts where heightened constraints operate on them. Recurrent features of translated language include explicitation, normalisation or ...