Browsing Research Output by Title
Now showing items 2778-2797 of 13384
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Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates
(RSC, 2016)The design, synthesis and biological evaluation of a series of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4- diamines is described. These compounds exhibited in vitro antiplasmodial activity in the low nanomolar range against ... -
Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase
(Springer, 2020)The most effective treatment of Parkinson’s disease is restoring central dopamine levels with levodopa, the metabolic precursor of dopamine. However, due to extensive peripheral metabolism by aromatic L-amino acid decarboxylase ... -
Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives
(Wiley, 2019)Tuberculosis is the deadliest infectious disease affecting humankind with a death toll of approximately 1.7 million people in 2016. The increasing prevalence of multidrug‐resistant strains of the causative pathogen, ... -
Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles
(MDPI, 2019)New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B. The most important chiral ... -
Design-based research: is this a suitable methodology for short-term projects?
(Taylor & Francis, 2016)This article reports on a design-based methodology of a thesis in which a fully face-to-face contact module was converted into a blended learning course. The purpose of the article is to report on how design-based phases, ... -
Design-reality gap assessment of an international distance education initiative
(Unisa Press, 2011)This article assesses a recently completed discontinued internationally funded e-education initiative at a South African higher education institution (HEI). The e-Learning Initiative in South Africa (Elisa) project was a ... -
Designing a digital pedagogical pattern for improving foreign language learners' oral proficiency
(AOSIS, 2016)South African undergraduate foreign language students need more opportunity to practise their oral language skills. Not only do appeals to focus more on oral productive skills feature in scholarly literature (Delena-le ... -
Designing a new methodology for customs risk models
(CCES, 2019)Effective risk management is a prerequisite to find an acceptable balance between the objectives of a customs operation and the streamlined flow of goods. The customs operations in many developing countries are characterised ... -
Designing a new science-policy communication mechanism for the UN Convention to Combat Desertification
(Elsevier, 2016)The United Nations Convention to Combat Desertification (UNCCD) has lacked an efficient mechanism to access scientific knowledge since entering into force in 1996. In 2011 it decided to convene an Ad Hoc Working Group on ... -
Designing and developing a narrative driven serious game for teaching information theory
(IEEE, 2018)A serious game called "Codebreakers" was developed and designed for a fourth year Telecommunications module at the University of Johannesburg. The goal of the game was to assist students to prepare for tests. The game was ... -
Designing public spaces through the lively planning integrative perspective
(Springer, 2015)The current sustainability-driven urban reality is complex. Planning for such a multidimensional environment is even more complex. Alternatives to traditional planning approaches are sought in an attempt to create liveable ... -
Designs from maximal subgroups and conjugacy classes of finite simple groups
(Charles Babbage Research Centre, 2016)Let G be a finite simple group, M be a maximal subgroup of G and Cg = nX be the conjugacy class of G containing g. In this paper we discuss a new method for constructing -(u, ? ?) designs D= (P,B), where P= nX and B = {(M?n ... -
The desire for the ineffable : on the myth of music as absolute : research article (2009/544)
(Buro vir Wetenskaplike Tydskrifte, Potchefstroom, 2009)This article proposes to establish and critique connections between religious and musico-aesthetic conceptions of in-effability by exploring the link between neoplatonic thought and romantic aesthetics. The central thesis ... -
A desire for weight loss in season increases disordered eating behaviour risk and energy deficiency in athletes
(MedPharm Publications, 2014)Objective: The objective was to explore eating behaviour, body image and energy status in female university team sport athletes. Design: This was a cross-sectional, descriptive study design. Setting: The setting was ... -
Destabilization dynamics of clay and acid-free polymers of ferric and magnesium salts in AMD without pH adjustment
(IWA Publishing, 2016)The physicochemical treatment was employed to treat acid mine drainage (AMD) in the removal of turbid materials using clay only (exp A) and a combination of clay, FeCl3 and Mg(OH)2 (exp B) to form a polymer. A 5 g sample ... -
Destoning of fine coal in a fluidized bed
(Springer, 2016)Water scarcity is driving the development of dry coal beneficiation processes. A lot of research has gone into the development of dry dense medium fluidized bed technology (DMFB), especially in China. However, these processes ... -
A detailed calculation of neutral hydrogen ionization frequencies used in turbulence transport models in the heliosphere
(EDP Sciences, 2015)It is generally accepted that the solar wind is significantly heated beyond ~10 AU by the turbulent decay of pickup ion generated Alfvénic fluctuations. Here, we present a detailed and general calculation of the pickup ion ... -
Detailed characteristics of coal ash from the largest coal-fired power plant in South America
(Swanson School of Engineering, Univ of Pittsburgh, 2015) -
Detailed characterization of SA high mineral matter inertinite–rich coals and density fractions and effect on reaction rates with carbon dioxide: macerals, microlithotypes, carbominerites and minerals
(SAIChE, 2013)An investigation was undertaken to determine the distribution of macerals and minerals in South African Highveld coal deposits as well as density fractions derived from a typical deposit. The corresponding effects on ...